摘要
目的 探讨血清脑源性神经营养因子(BDNF)、胃饥饿素(Ghrelin)与冠心病患者抑郁情绪的关系。方法 选择2019年2月~2021年2月106例冠心病患者为研究对象,采用汉密尔顿抑郁量表(HAMD)进行抑郁筛查,并设为抑郁组(重度亚组10例、中度亚组15例,轻度亚组17例)以及无抑郁组,分别为42例,64例,比较各组血清BDNF、Ghrelin水平,采用Pearson相关分析血清BDNF、Ghrelin水平与HAMD评分的关系,通过绘制ROC曲线判断血清BDNF、Ghrelin水平对冠心病合并抑郁诊断价值。结果 抑郁组血清BDNF、Ghrelin水平显著低于无抑郁组,重度亚组血清BDNF、Ghrelin水平显著低于中度亚组,中度亚组显著低于轻度亚组(P<0.05);血清BDNF、Ghrelin水平与HAMD评分呈显著负相关关系(P<0.05);ROC曲线显示,血清BDNF、Ghrelin水平诊断冠心病合并抑郁AUC值为0.99、0.93,临界值为0.15、0.24,敏感性为98.66%、95.23%,特异性为97.34%、 84.40%。结论 血清BDNF、Ghrelin水平与冠心病患者的抑郁情绪关系密切,与抑郁严重程度呈负相关关系,对冠心病合并抑郁可能具有一定的诊断价值。
Objective To explore relationship between serum BDNF,Ghrelin levels and the depression on coronary heart disease patients. Methods From February 2019 to February 2021,106 patients with coronary heart disease were selected as the research objects,and the Hamilton Depression Scale(HAMD)was used for depression screening,and set as the depression group(10 cases in the severe group,15 cases in the moderate group,and 17 cases in the mild group)and the non-depression group,42 cases and 64 cases respectively. Comparing the levels of serum BDNF and Ghrelin in each group. Pearson correlation analysis was used to analyze the relationship between serum BDNF,Ghrelin levels and HAMD score. The ROC curve was drawn to determine the value of serum BDNF and Ghrelin levels in the diagnosis of coronary heart disease complicated with depression. Results The levels of serum BDNF and Ghrelin in the depression group were significantly lower than those of the non-depression group,the levels of serum BDNF and Ghrelin in the severe group were significantly lower than those in the moderate group,and the moderate group were significantly lower than the mild group(P<0.05). Serum BDNF and Ghrelin levels were significantly negatively correlated with HAMD scores(P<0.05). The ROC curve showed that the AUC values of serum BDNF and Ghrelin levels for the diagnosis of coronary heart disease complicated with depression were 0.99 and 0.93,the cut-off values were 0.15 and 0.24,the sensitivity was 98.66% and 95.23%,and the specificity was 97.34% and 84.40%.Conclusion Serum BDNF and Ghrelin levels are closely related to depression on coronary heart disease patients,and negatively correlated with the severity of depression,and maybe have certain diagnostic value for coronary heart disease complicated with depression.
作者
程保玲
王小虎
田艳霞
CHENG Baoling;WANG Xiaohu;TIAN Yanxia(The First Outpatient Department of Henan Province,Zhengzhou 450003,China)
出处
《国际精神病学杂志》
2022年第1期87-89,96,共4页
Journal Of International Psychiatry
关键词
冠心病
抑郁
脑源性神经营养因子
胃饥饿素
Coronary heart disease
Depression
Brain-derived neurotrophic factor
Ghrelin
