摘要
结核病是全世界致死率较高的传染病之一,特别是耐药结核病的存在加重了全球疾病负担。儿童作为结核患者中的特殊群体,其临床症状不典型、检测标本采集困难、标本细菌载量低,故在疾病的诊断与治疗上均存在较大困难。近年来基于循证医学证据,出现了许多关于耐药结核病检测新技术及药物治疗新方案,但目前仍缺乏儿童相关的临床研究数据及指南、共识。儿童结核病的发病率影响未来成人结核患者的数量,重视儿童结核病对疾病控制具有重要意义,而对于儿童结核患者,快速准确的诊断及早期合理的治疗是关键。现对儿童耐药结核病诊断与治疗最新进展进行综述。
Tuberculosis is one of the infectious diseases with high mortality throughout the world,and drug-resistant tuberculosis in particular aggravates the global burden of disease.As a special group of tuberculosis patients,children have great difficulties in the diagnosis and treatment of diseases due to atypical clinical symptoms,difficulty in collecting test samples,and low bacterial load of samples.In recent years,based on medical evidence,many new detection techniques and drug treatment protocols for drug resistant tuberculosis have emerged,but there is still a lack of child-related clinical data and guideline consensus.The incidence of tuberculosis in children affects the number of adult tuberculosis patients in the future,and it is important to pay attention to tuberculosis in children for disease control,while for tuberculosis patients in children,rapid and correct diagnosis and early rational treatment are crucial.This article reviews the latest advance in the diagnosis and treatment of drug-resistant tuberculosis in children based on the available evidence.
作者
杨丹丹(综述)
陈军华(审校)
Yang Dandan;Chen Junhua(Department of Infectious Diseases,Children′s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)
出处
《国际儿科学杂志》
2022年第2期109-113,共5页
International Journal of Pediatrics
关键词
结核病
耐药
儿童
诊断
治疗
Tuberculosis
Drug resistance
Children
Diagnosis
Treatment
