摘要
目的探讨茵陈五苓糖浆联合人血白蛋白治疗新生儿高胆红素血症的临床疗效。方法选取2019年4月—2021年4月在南阳市中心医院治疗的98例高胆红素血症患儿,随机分为对照组(49例)和治疗组(49例)。对照组静脉滴注人血白蛋白,10 g加入5%葡萄糖注射液100 mL,1次/d。治疗组患者在对照组基础上口服茵陈五苓糖浆,10 mL/次,3次/d。两组患者连续用药5 d。观察两组患者临床疗效,比较治疗前后两组患者临床症状好转时间,血总胆红素(TBIL)和血间接胆红素(IBIL)水平,血清炎性因子白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)和C反应蛋白(CRP)水平,及不良反应情况。结果治疗后,治疗组患儿临床有效率明显高于对照组(97.96%vs 79.59%,P<0.05)。治疗后,治疗组临床症状好转时间明显早于对照组(P<0.05)。治疗后,两组患儿TBIL、IBIL水平,及血清炎性因子IL-8、IL-6、TNF-α、CRP水平明显低于治疗前(P<0.05),且治疗组显著低于对照组(P<0.05)。结论茵陈五苓糖浆与人血白蛋白联合治疗能显著提高临床有效率,有效降低胆红素及炎性反应,临床症状改善明显,药物不良反应减少。
Objective To investigate the curative effect of Yinchen Wuling Syrup combined with human albumin in treatment of neonatal hyperbilirubinemia. Methods Children(98 cases) with neonatal hyperbilirubinemia in Nanyang Central Hospital from April 2019 to April 2021 were randomly divided into control(49 cases) and treatment(49 cases) group. Children in the control group were iv administered with Human Albumin, 10 g added into 5% glucose injection 100 mL, once daily. Children in the treatment group were po administered with Yinchen Wuling Syrup on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms, serum bilirubin levels of TBIL and IBIL, levels of serum inflammatory factor IL-8, IL-6, TNF-α, and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(97.96% vs 79.59%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group(P < 0.05). After treatment, the levels of TBIL and IBIL, and serum inflammatory factors IL-8, IL-6, TNF-α and CRP in two groups were significantly lower than those before treatment, and these factors in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Yinchen Wuling Syrup combined with Human Albumin in treatment of neonatal hyperbilirubinemia can significantly improve the clinical effective rate,effectively reduce bilirubin and inflammatory reaction, improve clinical symptoms and reduce adverse drug reactions.
作者
齐玉敏
惠晓君
王岩
郭倩
王品
郝丽
QI Yu-min;HUI Xiao-jun;WANG Yan;GUO Qian;WANG Pin;HAO Li(Department of Neonatology,Nanyang Central Hospital,Nanyang 473000,China;Department of Gastroenterology,Affiliated Children’s Hospital of Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450000,China)
出处
《现代药物与临床》
CAS
2022年第1期104-108,共5页
Drugs & Clinic
基金
河南省医学科技攻关计划(2018020618)。
