摘要
目的探究新肤螨灵软膏联合异维A酸红霉素凝胶治疗寻常型痤疮的临床疗效。方法选取2019年5月—2021年5月南阳市中心医院收治的106例寻常型痤疮患者为研究对象,采用随机数字表法将所有患者分为对照组和治疗组,每组各53例。对照组取适量异维A酸红霉素凝胶涂抹于患处,1次/d。治疗组在对照组基础上取适量新肤螨灵软膏涂抹于面部,每日早上、睡眠各1次。两组患者连续治疗4周。观察两组的临床疗效,并比较治疗前后临床症状评分、皮脂分泌率(SER)、炎症因子水平。结果治疗后,治疗组患者的总有效率(92.45%)明显高于对照组(83.02%),组间比较差异具有统计学意义(P<0.05)。治疗后,两组红斑评分、色素沉着评分、银屑病皮损面积和严重程度指数(PASI)评分均显著降低(P<0.05),并且治疗后治疗组红斑评分、色素沉着评分、PASI评分均明显低于对照组(P<0.05)。治疗后,两组SER均降低(P<0.05),且治疗组SER低于对照组(P<0.05)。治疗后,两组患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平均显著降低(P<0.05),并且治疗组血清TNF-α、IL-1β、IL-6水平均低于对照组(P<0.05)。结论新肤螨灵软膏联合异维A酸红霉素凝胶可有效改善寻常型痤疮患者红斑、色素沉着,减轻机体炎症反应,有一定的临床推广应用价值。
Objective To explore the efficacy of Xinfu Manling Ointment combined with Isotretinoin Erythromycin Gel in treatment of acne vulgaris. Methods Patients(106 cases) with acne vulgaris in Nanyang Central Hospital from May 2019 to May 2021 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were given appropriate amount of Isotretinoin Erythromycin Gel, once daily. Patients in the treatment group were appropriate amount of Xinfu Manling Ointment on the basis of the control group, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the clinical symptom score, the sebum secretion rate(SER), and the levels of inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group(92.45%) was significantly higher than that of the control group(83.02%), and the difference was statistically significant(P < 0.05). After treatment, the erythema score,pigmentation score, and PASI score of two groups were significantly decreased(P < 0.05), and the erythema score, pigmentation score,and PASI score in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the SER in two groups were significantly decreased(P < 0.05), and the SER in the treatment group was lower than that in the control group(P <0.05). After treatment, the serum levels of TNF-α, IL-1β, and IL-6 in two groups were significantly decreased(P <0.05), and the serum levels of TNF-α, IL-1β, and IL-6 in the treatment group were significantly lower than those in the control group(P < 0.05).Conclusion Xinfu Manling Ointment combined with Isotretinoin Erythromycin Gel can effectively improve the erythema and pigmentation of patients with acne vulgaris, reduce the body’s inflammatory reaction, which has a certain clinical application value.
作者
陈小波
豆倩影
黄立新
王倩
郑新民
CHEN Xiao-bo;DOU Qian-ying;HUANG Li-xin;WANG Qian;ZHENG Xin-min(Department of Plastic Surgery,Nanyang Central Hospital,Nanyang 473000,China;Department of Dermatology,Nanyang Central Hospital,Nanyang 473000,China;Department of Dermatology,Henan Provincial People's Hospital,Zhengzhou 450003,China)
出处
《现代药物与临床》
CAS
2022年第1期146-150,共5页
Drugs & Clinic
基金
河南省医学科技攻关计划共建项目(SB201904011)。
