摘要
自古以来,延缓衰老、健康长寿是人们的普遍愿望。如今中国将人民健康放在优先发展的战略地位。如何维持健康的生命,减缓人体的衰老是值得关注的问题。人体衰老从微观层面上可表现为细胞衰老,细胞增殖与分化能力和生理功能逐渐发生衰退的变化过程即细胞衰老,细胞衰老是一种正常的生理功能,负责清除受损细胞,是组织损伤或急性应激后的再生和恢复。衰老是一种不可抗拒的自然规律,衰老不可避免,但延缓衰老是可能的。能量代谢是细胞功能的重要基础,是细胞利用糖、脂肪等营养物质产生三磷酸腺苷(ATP)的过程。线粒体通常被认为是细胞的发电站,也是糖、脂肪和氨基酸最终被氧化释放能量的地方。线粒体功能会随着年龄的增长而下降,线粒体动力学、活性氧含量、自噬、代谢物的改变会引起电子传递链、氧化磷酸化等功能失调,诱发线粒体功能失调。线粒体功能障碍是许多衰老相关疾病如神经退行性疾病、阿尔茨海默病、动脉粥样硬化等的内在发病原因之一。不良反应小且成分丰富的中药和安全有效的保健灸法越来越多的应用到延缓衰老领域中,这篇综述描述了线粒体功能对细胞衰老的影响,并就中医药及艾灸通过影响线粒体功能来延缓衰老这一机制对近年来国内外文献进行检索、分析、归纳与总结,以期望为该领域的未来深层次研究提供新的见解。
Since ancient times,delaying aging,health,and longevity have been the universal wish of people.Nowadays,China gives top strategic priority to the development of people's health.How to maintain a healthy life and slow down the aging of the human body is a problem worthy of our attention.Human aging can be shown as cell senescence from the microscopic level.Cell senescence is a process in which cell proliferation and differentiation and physiological function gradually decline.It is a normal physiological function responsible for the removal of damaged cells and is the regeneration and recovery of tissues after injury or acute stress.Aging is an irresistible natural law.Although it is inevitable,it is possible to delay aging.Energy metabolism is an important basis of cell function,in which cells use nutrients such as sugar and fat to produce adenosine triphosphate(ATP).Mitochondria serve as the cell's power stations,where sugars,fats,and amino acids are eventually oxidized to release energy.Mitochondrial function decreases with age.Changes in mitochondrial dynamics,reactive oxygen species content,autophagy,and metabolites can cause dysfunction of electron transport chain and oxidative phosphorylation,and induce mitochondrial dysfunction.Mitochondrial dysfunction is one of the internal causes of many aging-related diseases,such as neurodegenerative diseases,Alzheimer′s disease,and atherosclerosis.Chinese medicine with few side effects and rich ingredients and health care moxibustion with safety and efficacy have been widely applied to the field of anti-aging.This study reviewed the effect of mitochondrial function on cell senescence,and retrieved,analyzed,and summarized research papers on the mechanism of traditional Chinese medicine(TCM)and moxibustion in delaying aging by affecting mitochondrial function,which is expected to provide new insights for further research in this field.
作者
王慧
陈丽梅
单思
张高传
温晓梨
屠卓婧
刘红宁
WANG Hui;CHEN Li-mei;SHAN Si;ZHANG Gao-chuan;WEN Xiao-li;TU Zhuo-jing;LIU Hong-ning(Jiangxi University of Chinese Medicine,Nanchang 330004,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第7期254-267,共14页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江西民族传统药现代科技与产业发展协同创新中心项目(5241400101)
国家中医药管理局项目(GZY-GCS-2017-01)
国家中医药管理局《中医药传承与创新“百千万”人才工程(岐黄工程)》项目(国中医药人教函[2018]288号)。
关键词
线粒体
细胞衰老
中药
艾灸
mitochondria
cell senescence
Chinese medicine
moxibustion
