摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种由遗传、环境等多因素影响下导致的自身免疫性疾病,狼疮肾炎(lupus nephritis,LN)是SLE常见的并发症,也是终末期肾病(end stage renal disease,ESRD)最常见的继发性病因。在免疫反应过程中,T细胞的分化和功能受严格调节,以确保抵御病原体并防止自身免疫反应的发生,已知T细胞亚群与SLE的系统性自身免疫及器官炎症的发展密切相关,本文就T细胞的自身免疫耐受以及调节性T细胞、辅助性T细胞、自然杀伤T细胞、肾脏浸润T细胞在LN中的作用、机制及相关临床研究进展做一简要综述。
Systemic lupus erythematosus(SLE)is an autoimmune disease caused by multiple genetic and environmental factors.As a common complication of SLE,lupus nephritis(LN)is also the most common secondary cause of end-stage renal disease(ESRD).T cell differentiation and function are tightly regulated to ensure protection against pathogens and prevent autoimmune attack versus selfantigens.T cell subsets are critically involved in the development of systemic autoimmunity and organ inflammation in SLE.This review summarized the autoimmune tolerance of T cells and the roles and mechanisms of regulatory T,helper T,natural killer T and kidney-infiltrating T cells in LN as well as the relevant clinical researches.
作者
张令歌
刘晓茜
李露
Zhang Ling-ge;Liu Xiao-xi;Li Lu(First Affiliated Hospital,Xi'an Medical University,Xi'an 710077,China)
出处
《临床肾脏病杂志》
2022年第3期248-252,共5页
Journal Of Clinical Nephrology
基金
陕西省自然科学基础研究计划(S2021-JC-YB-1957)。
