摘要
本文采用不溶于水的L-谷氨酸作为拆分剂,在混合溶剂中对消旋α-苯乙胺进行拆分,拆分剂L-谷氨酸可以直接酸化高收率的回收。较好的反应条件是:拆分剂的用量1.05 mol,甲苯用量190 g,稀硫酸浓度15%。S-(-)-α-苯乙胺收率89%,比旋光度:-39.4°;回收混合a-苯乙胺收率92.5%;回收拆分剂收率95.9%,比旋光度:+31.2°。
In this paper,water-insoluble L-glutamic acid was used as the resolution agent to racemate in mixed solventsα-The resolution agent L-glutamic acid can be directly acidified and recovered in high yield.The better reaction conditions are as follows:the amount of resolution agent is 1.05 mol,the amount of toluene is 190 g,and the concentration of dilute sulfuric acid is 15%.S-(-)-α-phenylethylamine yield 89%,specific rotation:-39.40°;The recovery of mixedα-phenylethylamine was 92.5%;The yield of the recovered resolver was 95.9%,and the specific rotation was+31.20°.
作者
吴卫忠
蒋燕华
Wu Weizhong;Jiang Yanhua(School of Petrochemical Engineering,Changzhou University,Jiangsu Changzhou 213164;Changzhou Yincheng Pharmaceutical Co.Ltd.,Jiangsu Changzhou 213000)
出处
《化工时刊》
CAS
2022年第3期11-13,共3页
Chemical Industry Times
