摘要
Clinically,glaucoma patients often suffer from circadian rhythm(CR)disorder.It is well-known that the imbalance of CR can be one of the triggering mechanisms of glaucoma.However,as a disease involving neurodegeneration and mood dysregulation,glaucoma is more of a pathological process than a disease.Glaucoma pathogenesis exists throughout the whole process of life rhythm disorder,and its complex impact on CR deserves more attention.Glaucoma can cause CR disorder through a variety of mechanisms,while long-term CR disorder can lead to sleep disorder,depression,anxiety,metabolic syndrome and other related diseases,which in turn aggravate the process of glaucoma,forming a vicious cycle.Overall,glaucoma can affect the stability of CR not only by altering the optical signal reception,non-image-forming visual system,related hormone secretion and nerve damage,but also through mental disorders such as depression and anxiety.In this paper,we review the mechanism of glaucoma affecting CR in order to provide research ideas and therapeutic insights for glaucomatous CR disorder.
基金
supported by Regional Fund Project of National Natural Science Foundation of China(81860870)
Program of Chinese medicine innovative-Backbone talents of China(Xiang CM[2019]67)
Hunan Province"225"Program for Cultivation of High-level Health Talents(Xiang CM[2019]196)
Open Fund Project of Hunan Provincial Engineering Technology Research Center for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases and visual function protection with Chinese Medicine(2018YZD02).
