摘要
目的:观察乌灵胶囊联合盐酸帕罗西汀片治疗更年期抑郁症的临床疗效及对雌激素水平的影响。方法:选取更年期抑郁症患者100例,按随机数字表法分为研究组和对照组各50例。对照组给予盐酸帕罗西汀片治疗,研究组在对照组基础上给予乌灵胶囊治疗。比较2组临床疗效、汉密尔顿抑郁量表(HAMD)评分、睡眠质量、雌激素水平及不良反应。结果:研究组临床总有效率优于对照组,差异有统计学意义(χ_(2)=4.762,P=0.029)。治疗后,2组HAMD评分、匹兹堡睡眠质量量表(PSQI)评分均低于治疗前(P<0.05);研究组治疗后HAMD评分、PSQI评分低于对照组(P<0.05)。治疗后,2组促黄体生成素(LH)、血清卵泡刺激素(FSH)水平低于治疗前,雌二醇(E_(2))水平高于治疗前(P<0.05);研究组治疗后LH、FSH水平低于对照组,E_(2)水平高于对照组(P<0.05)。研究组不良反应总发生率为8.00%,低于对照组20.00%(χ_(2)=4.332,P=0.037)。结论:乌灵胶囊联合盐酸帕罗西汀片治疗更年期郁抑症临床疗效显著,可以减轻患者抑郁程度,提高睡眠质量,有效调节患者雌激素水平,降低药物不良反应。
Objective:To observe the clinical effect of the therapy of Wuling capsules combined with paroxetine hydrochloride tablets on menopausal depression.Methods:A total of 100 patients with menopausal depression were divided into the study group and the control group according to the random number table method,with 50 cases in each group.The control group was treated with paroxetine hydochloride tablets,and the study group was additionally treated with Wuling capsules based on the treatment of the control group.The clinical effects,scores of Hamilton Rating Scale for Depression(HAMD),sleep quality,estrogen levels and adverse reactions in the two groups were compared.Results:The total clinical effective rate in the study group was better than that in the control group,the difference being significant(χ_(2)=4.762,P=0.029).After treatment,the scores of HAMD and PSQI in both groups were lower than those before treatment(P<0.05);after treatment,the above scores in the study group were lower than those in the control group(P<0.05).After treatment,the levels of luteinizing hormone(LH)and serum follicle stimulating hormone(FSH)in the two groups were lower than those before treatment,and the estradiol(E_(2))level was higher(P<0.05);after treatment,the levels of LH and FSH in the study group were lower than those in the control group,and the E_(2) level was higher(P<0.05).The total incidence of adverse reactions was 8.00%in the study group,lower than that of 20.00%in the control group(χ_(2)=4.332,P=0.037).Conclusion:The therapy of Wuling capsules combined with paroxetine hydrochloride tablets for menopausal depression has a significant clinical effect,which can lessen the degree of depression,improve the sleep quality,effectively regulate the estrogen levels,and reduce the adverse reactions.
作者
王良雪
黄健飞
WANG Liangxue;HUANG Jianfei
出处
《新中医》
CAS
2022年第5期131-134,共4页
New Chinese Medicine
关键词
更年期
抑郁症
乌灵胶囊
盐酸帕罗西汀片
雌激素
汉密尔顿抑郁量表
睡眠质量
不良反应
Menopause period
Depression
Wuling capsules
Paroxetine hydrochloride tablets
Estrogen
Hamilton Rating Scale for Depression
Sleep quality
Adverse reactions
