摘要
自从电子起搏器进入临床以来,无数房室传导阻滞和病态窦房结综合征患者的生活质量得到了极大改善,但它仍存在感染、缺乏生理反应性和电池寿命有限等问题。生物起搏就此应运而生,生物起搏核心的问题是获得和正常窦房结细胞具有相同功能的起搏细胞,目前调控生物起搏细胞生成的方法多种多样,例如可通过单基因、多基因联合以及信号通路调控等方法来构建生物起搏细胞,现就当前生物起搏细胞的调控方法做一综述。
Since the electronic pacemaker entered the clinic,the quality of life of countless patients with atrioventricular block and sick sinus syndrome has been greatly improved,but it still has some problems,such as infection,lack of physiological reactivity and limited battery life.Biological pacemaker aims to solve these problems,and its core issue is to acquire pacemaker cells with the same function as normal sinoatrial node cells.There are many ways to regulate biological pacemaker cells,such as single-gene,multigene combination and signal pathway regulation and so on.This paper reviews the current regulation methods of biological pacemaker cells.
作者
刘江文
杨双
唐艳红
黄从新
LIU Jiangwen;YANG Shuang;TANG Yanhong;HUANG Congxin(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute of Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2022年第3期203-206,共4页
Advances in Cardiovascular Diseases
基金
湖北省技术创新专项(重大项目)(2016ACA153)。
关键词
生物起搏
基因调控
联合基因转染
Biological pacemaker
Gene regulation
Combined gene transfection
