摘要
目的分析纳洛酮治疗急性酒精中毒的疗效及安全性。方法选取2019年1月至2019年12月本院收治的100例急性酒精中毒患者,按照随机数字表法1:1配对原则分为观察组(n=50)、对照组(n=50),其中对照组给予常规治疗,观察组给予常规治疗+纳洛酮,对比两组疗效、病情改善情况、血清肌酸激酶(CK)、乳酸(LA)、丙二醛(MDA)、β-内啡肽(β-EP)、肝功能[丙氨酸氨基转移酶(ALT)天门冬氨酸氨基转移酶(AST)]水平、氧代谢[动脉血氧含量(CaO_(2))、血氧饱和度(SaO_(2))及氧输送(DO_(2))]水平及安全性。结果观察组治疗有效率94.00%(47/50)显著高于对照组70.00%(35/50)(P<0.05);观察组呼吸频率恢复、苏醒、GCS评分达8分、症状消失及出院时间均明显短于对照组(P<0.05);治疗后观察组CK、LA、ALT、AST水平均低于对照组(P<0.05);治疗后观察组血清MDA、β-EP水平低于对照组,DO_(2)、CaO_(2)、SaO_(2)水平高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论纳洛酮治疗急性酒精中毒疗效确切,可有效改善病情,提高肝功能及氧代谢水平,且具有一定安全性。
Objective To analyze the efficacy and safety of naloxone in the treatment of acute alcoholism.Methods From January 2019 to December 2019,100 patients with acute alcoholism were divided into observation group(N=50)and control group(N=50)according to the 1:1 matching principle of random number table,the control group was given routine treatment,the observation group was given routine treatment plus naloxone,the therapeutic effect,disease improvement,serum creatine kinase(CK),lactate(LA),malondialdehyde(MDA),β-endorphin(β-EP),liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST)],oxygen metabolism[arterial oxygen content(CaO_(2)),oxygen saturation(SaO_(2))and oxygen delivery(DO_(2))]levels and safety were compared between the two groups.Results The total effective rate of the observation group was 94.00%(47/50)significantly higher than that of the control group(70.00%(35/50)(P<0.05),and the recovery of respiratory frequency,awakening,GCS score up to 8,symptom disappearance and discharge time of the observation group were significantly shorter than that of the control group(P<0.05).After treatment,the levels of CK,LA,ALT and AST in the observation group were lower than those in the control group(P<0.05),the levels of MDA andβ-EP in the observation group were lower than those in the control group,and the levels of DO_(2),CaO_(2) and SaO_(2) were higher than those in the control group(P<0.05);The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Naloxone is effective and safe in the treatment of acute alcoholism,which can improve the condition,liver function and oxygen metabolism.
作者
马迎春
马英姿
MA Yingchun;MA yingzi(Department of Outpatient,Hebi people's Hospital,Hebi Henan 458000,China;Department of Orthopedics,Hebi people's Hospital,Hebi Henan 458000,China)
出处
《临床研究》
2022年第1期44-47,共4页
Clinical Research
关键词
急性酒精中毒
纳洛酮
肝功能
氧代谢
安全性
acute alcoholism
naloxone
liver function
oxygen metabolism
safety
