期刊文献+

Multiscale design and biomechanical evaluation of porous spinal fusion cage to realize specified mechanical properties 被引量:1

下载PDF
导出
摘要 Backgrou nd Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody fusion.However,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shielding and cage subsidence.Methods The current study presents a multiscale optimization approach for porous Ti fusion cage development,including microscale topology optimization based on homogenization theory that obtains a unit cell with prescribed mechanical properties,and macroscale topology optimization that determines the layout of framework structure over the porous cage while maintaining the desired stiffness.The biomechanical performance of the designed porous cage is assessed using numerical simulations of fusion surgery.Selective laser melting is employed to assists with fabricating the designed porous structure and porous cage.Results The simulations demonstrate that the designed porous cage increases the strain energy density of bone grafts and decreases the peak stress on bone endplates.The mechanical and morphological discrepancies between the as-designed and fabricated porous structures are also described.Conclusion From the perspective of biomechanics,it is demonstrated that the designed porous cage contributes to reducing the risk of stress shielding and cage subsidence.The optimization of processing parameters and post-treatments are required to fabricate the designed porous cage.The present multiscale optimization approach can be extended to the development of cages with other shapes or materials and further types of orthopedic implants.
出处 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2022年第2期277-293,共17页 生物设计与制造(英文)
基金 financially supported by the National Natural Science Foundation of China(No.51975336) the Key Basic Research Project of Natural Science Foundation of Shandong Province,China(No.ZR2018ZB0106) the Key Research and Development Program of Shandong Province,China(No.2019JZZY010112)。
  • 相关文献

参考文献4

二级参考文献26

  • 1van CLEYNENBREUGEL T, van OOSTERWYCK H, VANDER SLOTEN J, SCHROOTEN J. Trabecular bone scaffolding using a biomimetic approach [J]. Journal of Materials Science: Materials in Medicine, 2002, 13: 1245-1239.
  • 2YOO D J. Computer-aided porous scaffold design for tissue engineering using triply periodic minimal surfaces [J]. International Journal of Precision Engineering and Manufacturing, 2011, 12(1): 61-71.
  • 3LIN L, HU Q, HUANG X, XU G. Design and fabrication of bone tissue engineering scaffolds via rapid prototyping and CAD [J]. Journal of Rare Earths, 2007, 25: 379-383.
  • 4HOLLISTER S J, LIN C Y. Computational design of tissue engineering scaffolds [J]. Computer Methods in Applied Mechanics and Engineering, 2007, 196:2991-2998.
  • 5KANG H, L1N C Y, HOLLISTER S J. Topology optimization of three dimensional tissue engineering scaffold architectures tbrprescribed bulk modulus and diffusivity [J]. Structural and Multidisciplinary Optimization, 2010, 42: 633-644.
  • 6OH I H, NOMURA N, MASAHASHI N, HANADA S. Mechanical properties of porous titanium compacts prepared by powder processing [J]. Scripta Materialia, 2003, 49:1197-1202.
  • 7BRAM M. High-porosity titanium, stainless steel, and superalloy parts [J]. Advanced Engineering Materials, 2000, 2:196-199.
  • 8MIYAO R, OMORI M, WATAR/F, YOKOYAMA A, MATSUNO H, HIRAI T, KAWASAKI T. Fabrication of functionally graded implants by spark plasma sintering and their properties [J]. Journal of the Japan Society of Powder and Powder Metallurgy, 2000, 47: 1239-1242.
  • 9BOBYN J D, STACKPOOL G J, HACKING S A, TANZER M, KRYGIER J J. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial [J]. Journal of Bone & Joint Surgery, 1999, 81: 907-914.
  • 10GUY W, YONG M S, TAY B Y, LIM C S. Synthesis and bioactivity of porous Ti alloy prepared by foaming with Till2 [J]. Materials Science and Engineering C, 2009, 29(5): 1515-1520.

共引文献17

同被引文献2

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部