摘要
肉苁蓉是一种珍贵的滋补类药材,素有“沙漠人参”的美誉,具有极高的药用价值和食用价值。药理学研究已确认肉苁蓉具有抗氧化、抗炎、抗疲劳、抗衰老、抗骨质疏松、润肠通便、保肝、免疫调节等药理作用,其中苯乙醇苷类是其主要活性成分之一。近年来,肉苁蓉苯乙醇苷类成分抗骨质疏松的作用得到广泛关注,松果菊苷和毛蕊花糖苷是其代表性成分,笔者总结了国内外肉苁蓉中苯乙醇苷类成分的文献资料,对其体内外代谢转化过程和产物以及抗骨质疏松的药效学与作用机制的研究进展进行综述,以期为肉苁蓉的实验研究、药物和保健食品开发及临床应用提供参考。
Cistanche deserticola is a kind of precious nourishing medicinal material,known as“desert ginseng”,with high medicinal and edible value.Pharmacological studies have confirmed that Cistanche deserticola has anti-oxidation,anti-inflammation,anti-fatigue,anti-aging,anti-osteoporosis,moistening bowel laxative,liver protection,immune regulation and other pharmacological effects,among which phenylethanolside is one of its main active components.In recent years,the anti-osteoporosis effect of phenyleth anol glycosides in Cistanche deserticola has attracted widespread attention.Echinacoside and verbascoside are the representative components,but their anti-osteoporosis mechanism has not been fully elucidated.This article summarizes the literature data of phenethyl alcohol glycosides in Cistanche deserticola at home and abroad,and summarizes the research progress of its metabolic transformation process and products in vivo and in vitro,as well as the pharmacodynamics and mechanism of anti-osteoporosis,in order to provide reference for the experimental research,drug and health food development and clinical application of Cistanche deserticola.
作者
郑玉玲
李纳纳
冯京
张浩
丁辉
宋新波
ZHENG Yuling;LI Nana;FENG Jing;ZHANG Hao;DING Hui;SONG Xinbo(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Hongri Pharmaceutical Co.Ltd.,Tianjin 301617,China)
出处
《天津中医药大学学报》
CAS
2022年第2期265-272,共8页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家重点研发计划项目(2016YFC0501007-03)。
关键词
肉苁蓉
苯乙醇苷类
体内外代谢
抗骨质疏松
药效学
作用机制
Cistanche deserticola
phenylethanolglycosides
in vivo and in vitro metabolism
anti-osteoporosis
pharmacodynamics
mechanism
