摘要
黏液屏障是黏膜给药系统需要应对的一大生理障碍,应对这一生理屏障,研究者开展了大量关于黏膜黏附和黏液穿透的工作,并取得一定成果。本文主要介绍了关于阳离子化、巯基化、马来酰亚胺功能化、凝集素化及儿茶酚缀合等新型黏膜黏附策略;聚乙二醇、聚乙烯醇、聚(2-烷基-2-恶唑啉)和两性离子聚合物等黏液惰性材料,以及酶功能化、还原剂预处理等增强黏液穿透能力的研究,并分析各策略存在的问题,以期为临床转化提供参考。
The mucous barrier is a major physiological obstacle that the mucosal drug delivery system needs to deal with. In response to this physiological barrier, many achievements have been made in research of mucosal adhesion and mucus penetration. This review puts emphasis on the progress of the research on new mucosal adhesion strategies such as cationization, sulfhydrylization, maleimide functionalization, lectinization and catechol conjugation;polyethylene glycol(PEG), polyvinyl alcohol(PVA), poly(2-alkyl-2-oxazoline)(POZ), zwitterionic polymers and other mucus-inert materials, strategies to enhance mucus penetration ability such as enzyme functionalization, reducing agent pretreatment and so on. The problems of each strategy are also analyzed and discussed, which can provide some references for clinical transformation.
作者
吕风梅
随力
刘哲鹏
Lü Feng-mei;SUI Li;LIU Zhe-peng(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第3期670-680,共11页
Acta Pharmaceutica Sinica
关键词
黏膜给药
黏液屏障
黏膜黏附
黏液惰性
黏液穿透
mucosal drug delivery
mucus barrier
mucosal adhesion
muco-inert
mucus penetration
