摘要
从中药材的"一物多效"现象,分析现行药材商品规格等级标准存在的问题和研究现状。依据多效中药"定向药效成分"与"中药质量标志物(quality marker,Q-Marker)"研究原则提出在功能分类评价下发现"定效Q-Marker"的药材商品规格等级标准研究策略,旨在诠释中药在方剂中的选择性功效取向,准确评控药材质量。通过阐明药材功效-成分-品质特征,在现行药材商品规格等级标准的基础上修订完善,为建立评价质量优劣的标准提供新思路,为中药材的精准分类应用,进而提高中医药疗效提供科学支撑。
According to the phenomenon of “multi-effect for one substance” of Chinese materia medica,the existing problem and research status of the current commodity specification and grade standard were analyzed.The thought was put forward based on oriented effective components of multi-effect herbs and five principles of quality marker(Q-Marker) of Chinese materia medica.This research strategy was that the standard of commodity specification and grade should be revised using oriented effective Q-Markers after the effects of Chinese materia medica were classified.The aim is to interpret the selective efficacy orientation in the formula and evaluate the quality of Chinese materia medica accurately.The relationships were elucidated about “effect-components-quality characteristic” of Chinese materia medica,and then the current commodity specification and grade standard was revised and perfect,which could provide a new thought for establishing quality standard,and the scientific support for classified application of Chinese materia medica precisely,then further improving the therapeutic effect of traditional Chinese medicine.
作者
何盼
李震宇
刘月涛
王智超
杜冠华
秦雪梅
HE Pan;LI Zhen-yu;LIU Yue-tao;WANG Zhi-chao;DU Guan-hua;QIN Xue-mei(Modern Research Center for Traditional Chinese Medicine of Shanxi University,Taiyuan 030006,China;Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Shanxi University,Taiyuan 030006,China;Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第6期1868-1874,共7页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(31770362)
国家重点研发计划项目(2019YFC1710800)
地产中药功效物质研究与利用山西省重点实验室(201605D111004)。
关键词
中药材
商品规格等级
一物多效
质量标志物
质量评价
Chinese materia medica
commodity specification and grade
multi-effect for one substance
quality marker
quality evaluation
