摘要
人类恶性肿瘤由于缺乏早期相关特异性诊断标志物,患者被诊断时往往已处于疾病晚期,且手术、化疗和放疗等常规治疗方法效果不佳,导致患者病死率较高。近年来关于再生基因(Reg)家族的研究备受关注,Reg不仅可调控正常肝脏、胰腺、胃、肠等器官细胞的增殖和分化,还在多种人类恶性肿瘤中异常表达,与肿瘤的发生、发展、侵袭、转移及预后均密切相关。因此,探究Reg家族与人类恶性肿瘤的关系,有助于深入了解恶性肿瘤的发生、发展机制以及寻找潜在的恶性肿瘤早期诊断标志物和治疗靶点。
Due to the lack of early and specific diagnostic markers for human malignancies,the patients are often diagnosed at advanced stages of the disease,and conventional treatments such as surgery,chemotherapy and radiotherapy are ineffective,resulting in a high death rate.In recent years,much attention has been paid to the study of the regenerative gene(Reg)family,which not only regulates the proliferation and differentiation of normal liver,pancreas,stomach and intestine cells,but also is aberrantly expressed in a variety of human malignancies and is closely related to tumorigenesis,development,invasion,metastasis and prognosis.Therefore,exploring the relationship between the Reg family and human malignancies can help to gain insight into the mechanisms of malignancy occurrence and development as well as to discover potential early diagnostic markers and therapeutic targets for malignancies.
作者
董雪成
倪金良
彭波
DONG Xuecheng;NI Jinliang;PENG Bo(Department of Urology,Cixi People′s Hospital Medical and Health Group(Cixi People′s Hospital),Cixi 315300,China;Shanghai Clinical College,Anhui Medical University,Shanghai 200072,China;Department of Urology,the Tenth People′s Hospital,Tongji University School of Medicine,Shanghai 200072,China)
出处
《医学综述》
CAS
2022年第5期922-928,共7页
Medical Recapitulate
基金
上海市科学技术委员会科研计划项目(19140905700)
宁波市科技计划项目(2018A610300)。
关键词
恶性肿瘤
再生基因家族
诊断标志物
治疗靶点
Malignant tumor
Regenerating gene family
Diagnostic marker
Therapeutic target
