摘要
组织内的间充质干细胞是人体重要的间充质干细胞来源,作为组织间充质干细胞的一种,肺常驻间充质干细胞(LR-MSC)主要位于肺泡微血管壁中,具有与骨髓间充质干细胞相似的特性,但在治疗肺部疾病时的效果较骨髓间充质干细胞更好。特发性肺纤维化(IPF)是一种以局部组织破坏和细胞外基质沉积为特征的不可逆性慢性肺部疾病,在病理条件下,LR-MSC参与IPF的发病过程,其受部分细胞因子的驱动可分化为成纤维细胞、血管内皮细胞,进而促进肺局部组织纤维化和微血管重构,因此深入研究其具体作用机制对IPF的治疗具有重要意义。
Tissue resident mesenchymal stem cell is an important origin of mesenchymal stem cell in human body.As one of the tissue resident mesenchymal stem cell,lung-resident mesenchymal stem cell(LR-MSC)is mainly located in alveolar microvascular wall,which has similar characteristics to bone marrow mesenchymal stem cell,but has better therapeutic effect than bone marrow mesenchymal stem cell when treating lung diseases.Idiopathic pulmonary fibrosis(IPF)is an irreversible chronic pulmonary disease with the features of partial tissue destruction and extracellular matrix deposition.Under pathological condition,LR-MSCs are involved in the progression of IPF,and these LR-MSCs are driven by some cytokines and differentiate into fibroblast cell,vascular endothelial cell,thus accelerate partial lung tissue fibrosis and micro vascular reconstruction.In-depth understanding of the specific mechanisms of action is of great significance for the treatment of IPF.
作者
林浩辉
赵振富
蔡飒
LIN Haohui;ZHAO Zhenfu;CAI Sa(Shenzhen University Health Science Center,Shenzhen 518061,China)
出处
《医学综述》
CAS
2022年第6期1041-1045,共5页
Medical Recapitulate
基金
国家自然科学基金(82072163)。
关键词
特发性肺纤维化
肺常驻间充质干细胞
肺纤维化
Idiopathic pulmonary fibrosis
Lung-resident mesenchymal stem cell
Pulmonary fibrosis
