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金银花中重金属污染分析及其健康风险评估 被引量:17

Analysis of heavy metal pollution in Lonicerae Japonicae Flos and its health risk assessment
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摘要 该研究采用电感耦合等离子体质谱法(ICP-MS)测定59批金银花药材和饮片中铅(Pb)、镉(Cd)、砷(As)、汞(Hg)、铜(Cu)5种重金属含量,通过计算每日最大可耐受摄入量(EDI)、靶标危害系数(THQ)和致癌风险(CR)风险评估模型,进行健康风险评估。参照《中国药典》2020年版金银花项下重金属含量限量标准,所测定59批次样品中,除河北产区的5批药材样品Pb超标外,其余54批均符合规定,不合格率为8.47%。经对山东、河南、河北三大产区金银花药材重金属含量对比研究发现,Pb、As、Hg的含量以河北产样品含量最高,显著高于河南、山东产样品;而Cd的含量以山东产样品最高;Cu的含量以河北产样品最高,山东产样品含量最低。同时,健康风险评估模型EDI、THQ和CR结果显示,该研究中59批次金银花样品未对暴露人群造成明显的健康影响,不存在潜在的非致癌或致癌风险。综上,金银花中仍存在部分样品重金属超标现象,应从其产区环境、栽培管理模式、加工方式等环节上加以控制,以保证金银花的用药安全。 In this study,the content of five heavy metals(Pb,Cd,As,Hg,and Cu)in 59 batches of Lonicerae Japonicae Flos(LJF)medicinal materials and pieces were determined by inductively coupled plasma mass spectrometry(ICP-MS).The health risk assessment was processed using the maximum estimated daily intake(EDI),target hazard quotients(THQ),and carcinogenic risks(CR)assessment models.With reference to the limit standard for heavy metal content in LJF specified in 2020 edition of Chinese Pharmacopoeia,five batches produced in Hebei were found to contain excessive Pb,and the remaining 54 batches met the specifications,with the unqualified rate of 8.47%.Comparative analysis of heavy metal content in LJF samples from three different producing areas,namely Shandong,Henan,and Hebei showed that the levels of Pb,As,and Hg in LJF from Hebei were significantly higher than those from Henan and Shandong.The samples produced in Shandong contained the highest content of Cd.The samples from Hebei contained the highest content of Cu while those from Shandong had the lowest content of Cu.As demonstrated by health risk assessment based on the EDI,THQ and CR models,these 59 batches of LJF samples did not cause significant health hazards for the exposed population,and there was no potential non-carcinogenic or carcinogenic risk.In conclusion,a few of LJF samples contained excessive heavy metals,so some measures,including controlling production environment,cultivating management mode,and optimizing processing methods,should be taken for ensuring the medication safety of LJF.
作者 卜桐 于晓 张欣芮 李佳 王玲娜 张芳 张永清 BU Tong;YU Xiao;ZHANG Xin-rui;LI Jia;WANG Ling-na;ZHANG Fang;ZHANG Yong-qing(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China;Shandong Medicine Technician College,Taian 271016,China)
出处 《中国中药杂志》 CAS CSCD 北大核心 2022年第3期643-650,共8页 China Journal of Chinese Materia Medica
基金 山东省重大科技创新项目(2019JZZY011020) 山东省中医药科技项目(2020Z02) 国家重点研发计划项目(2017YFC1701503) 国家自然科学基金项目(81903750)。
关键词 金银花 重金属 电感耦合等离子体质谱 健康风险评估 Lonicerae Japonicae Flos heavy metal inductively coupled plasma mass spectrometry(ICP-MS) health risk assessment
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