摘要
金属有机框架(MOFs)在气体储存与分离、燃料电池、能源转换,以及化学/生物传感器的构建等领域均发挥着重要作用。当MOFs的尺寸在一个维度上小于100 nm时,即为纳米金属有机框架(nMOFs)。与传统的MOFs相比,nMOFs不仅保持了原有的高度有序多孔结构,还具有结构可调、表面修饰位点更加有效,以及生物分子分布功能增强等优势。用生物相容性的分子制备或修饰nMOFs,在生物医学尤其是肿瘤和肿瘤标志物的检测方面也具有很大的应用潜力。该综述总结了nMOFs用于肿瘤和肿瘤标志物的成像检测技术(包括荧光、核磁共振、超声、断层扫描、发射断层,以及多模态成像等)的最新进展,并对该领域的发展进行了展望,对nMOFs介导的药物载体在未来临床癌症治疗方面的可能应用进行了讨论。
Metal-organic frameworks(MOFs)have played important roles in a wide range of fields,such as gas stor⁃age and separation,fuel cells,energy conversion,and chemical/biological sensors.When one of the dimensions is scaled down to nanometer,MOFs can be named as nanoscale MOFs(nMOFs).Compared with the traditional MOFs,nMOFs retain the advantages of highly ordered porosity,structural tunability,more effective surface modification sites and improved biological distributions.nMOFs are biocompatible molecular nanomaterials with great potentials in various biomedical applications,especially for detection of tumors and tumor markers.In this review,recent prog⁃ress in nMOFs for biological imaging of tumors and tumor markers is summarized.Different bioimaging techniques in⁃cluding fluorescence imaging,magnetic resonance imaging(MRI),photoacoustic imaging(PAI),computed tomogra⁃phy imaging(CTI),positron emission tomography imaging(PETI)are introduced.After that,multimodal imaging superimposed by two or more imaging modalities is highlighted.Finally,a brief conclusion about this special field is provided.Priorities of research in nMOF-mediated therapies and the prospects of clinical applications of nMOFs as de⁃livery carriers and cancer therapeutics are also outlined.This review is expected to advance our understanding of this special field,and promote the applications of nMOFs in early diagnosis of disease and tumor therapy.
作者
廖学巍
刘旸
王琛
LIAO Xue-wei;LIU Yang;WANG Chen(Analytical&Testing Center,Nanjing Normal University,Nanjing 210023,China;School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China;School of Environment,Nanjing Normal University,Nanjing 210023,China;State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University,Nanjing 210023,China)
出处
《分析测试学报》
CAS
CSCD
北大核心
2022年第4期476-485,共10页
Journal of Instrumental Analysis
基金
the National Natural Science Foundation of China(22022412,21874155,22104060)
the Natural Science Foundation of Jiangsu Province(BK20200716,BK20191316)
the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(20KJB150019)
Innovation and Entrepreneurship Doctor Program of Jiangsu Province(JSSCBS20210317)
the State Key Laboratory of Analytical Chemistry for Life Science(SKLACLS2106)
the Qing-Lan Project of Jiangsu Province(2019)。
关键词
纳米金属有机框架
生物成像
肿瘤标志物
生物医药
nanoscale metal-organic frameworks(nMOFs)
biological imaging
tumor markers
biomedicine
