摘要
患者男,26岁,额部褐色斑块4年。皮肤科情况:额部见一约3 cm×4 cm大小浸润性浅褐色斑块,触之硬,中央见破溃,皮损处皮温正常,无压痛。皮损组织病理示:表皮无明显异常,真皮层肿瘤组织,浅层见微囊肿及角囊肿,可见管腔形成,腔内见嗜酸性物质。深部肿瘤细胞小叶状实性上皮巢和上皮条索状排列,上皮条索由嗜碱性基底样细胞及腺管状组成。免疫组织化学:CK(+)、BerEp4(+)、EMA部分肿瘤细胞及管腔侧缘(+)、CEA(-)、S-100(-)、Ki-67阳性细胞约10%。诊断:微囊性附属器癌。
A 26-year-old man presented with a 4-year history of a brown patches on the forehead.Dermatology examination showed an infiltrating light brown plaque(approximately 3 cm×4 cm)on the forehead,which was slightly hard without tenderness and with ulcer in the center of the lesion;the skin temperature of the lesion was normal.Histopathological examination revealed no obvious abnormalities in the epidermis,but there was tumor tissue in the dermis.In the superficial layer,there were microcysts,horn cyst and also lumen formation in which there was eosinophilic substances.Deep tumor cells had lobular solid epithelial nests and epithelial cords,which were composed of basophilic basal-like cells and glandular tubes.The immunohistochemistry revealed positive CK,BerEp4,some tumor cells of EMA and luminal margin.It was negative for CEA and S-100.The Ki-67 positive cells were approximately 10%.The diagnosis of microcystic adnexal carcinoma was made.
作者
冉德琳
刘永霞
周桂芝
杨宝琦
RAN Delin;LIU Yongxia;ZHOU Guizhi;YANG Baoqi(Shandong Provincial Hospital for Skin Disease&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2022年第3期334-337,共4页
The Chinese Journal of Dermatovenereology
关键词
微囊性附属器癌
微囊肿
免疫组织化学
Microcystic adnexal carcinoma
Microcyst
Immunohistochemistry
