摘要
目的对小儿川崎病采用不同剂量丙种球蛋白治疗的效果进行探究。方法选择本院收治的小儿川崎病患者52例纳入到研究当中,选取时间:2018年9月—2020年9月。通过随机盲选的方式对这些患儿予以分组,划分为甲组和乙组,每组26例。甲组患儿接受低剂量丙种球蛋白治疗,乙组患儿接受高剂量丙种球蛋白治疗。对比两组患儿的治疗效果。结果甲组的总有效率为69.2%,乙组的总有效率为92.3%,乙组的总有效率明显高于甲组,数据差异有统计学意义(P<0.05);治疗前,乙组的IL-6、IL-8、TNF-α等血清炎性因子水平与甲组比较差异无统计学意义(P>0.05),治疗后,乙组的IL-6为(6.9±0.7)pg/mL,IL-8为(5.9±1.1)pg/mL,TNF-α为(1.0±0.1)pg/mL,明显低于甲组的(8.2±0.9)、(6.9±1.4)、(1.3±0.3)pg/mL,数据差异有统计学意义(P<0.05)。乙组的手足肿胀缓解时间为(2.1±0.4)d,黏膜充血缓解时间为(3.9±0.3)d,颈部淋巴结肿大缓解时间为(3.2±0.4)d,明显短于甲组的(4.5±0.5)、(6.3±0.7)、(5.9±0.7)d,数据差异有统计学意义(P<0.05)。结论在小儿川崎病的临床治疗中,采用高剂量丙种球蛋白治疗具有很好的效果,可以有效改善患儿的血清炎性因子水平,促进其各项临床症状的改善。
Objective To investigate the effect of different doses of gamma globulin in the treatment of children with Kawasaki disease.Methods A total of 52 pediatric patients with Kawasaki disease admitted to our hospital were included in the study.The selection time was from September 2018 to September 2020.These children were divided into group A and group B by blind random selection,with 26 cases in each group.Children in group A received low dose of gamma globulin and children in group B received high dose of gamma globulin.The therapeutic effect of the two groups was compared.Results The total effective rate of group A was 69.2%,and that of group B was 92.3%.The total effective rate of group B was significantly higher than that of group A,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of IL-6,IL-8,TNF-αand other inflammatory factors between group B and group A(P>0.05).After treatment,IL-6 and IL-8 were(6.9±0.7)pg/mL and(5.9±1.1)pg/mL respectively.TNF-αwas(1.0±0.1)pg/mL,significantly lower than(8.2±0.9),(6.9±1.4),(1.3±0.3)pg/mL in group A,and the difference was statistically significant(P<0.05).The relief time of hand and foot swelling,mucosal hyperemia and cervical lymph node enlargement in group B was(2.1±0.4),(3.9±0.3)d and(3.2±0.4)d,which were significantly shorter than(4.5±0.5),(6.3±0.7)d and(5.9±0.7)d in group A.The difference was statistically significant(P<0.05).Conclusion In the clinical treatment of children with Kawasaki disease,the use of high dose of gamma globulin therapy has a good effect,can effectively improve the level of serum inflammatory factors,promote the improvement of their clinical symptoms.
作者
胡彪
HU Biao(Department of Pediatrics,Changsha Third Hospital,Changsha Hu’nan 410000,China)
出处
《中国卫生标准管理》
2022年第6期117-120,共4页
China Health Standard Management
关键词
小儿川崎病
高剂量
丙种球蛋白
疗效
血清炎性因子
症状缓解时间
pediatric Kawasaki disease
high dose
gamma globulin
curative effect
serum inflammatory factors
symptom relief time
