摘要
Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5].
基金
supported by the National Key Research and Development Program of China(2017YFB0403801)
the National Natural Science Foundation of China(31971096 and 31771256)
the Sigma Xi Grants in Aid of Research(GIAR)program(G03152021115804390).
