摘要
目的:提出一种基于排污效率的高生物安全风险车间的气流组织评价方法。方法:以用于生产新型冠状病毒疫苗的核心生产区为例,采用RNG k-ε湍流模型,应用计算流体力学方法进行核心生产区内流场变化的计算,采用离散相模型进行病毒颗粒物的计算。以排污效率和排空时间作为评价指标,比较病毒颗粒物于冰箱表面散发(情况一)和于隔离器顶部散发(情况二)2种情况下的污染物排除效果。结果:核心生产区整体上气流分布均匀,但局部存在小的涡流;在持续散发的情况下,病毒颗粒物在第280秒会扩散至整个房间;情况一、情况二的污染物排空时间分别为556、771 s,排污效率分别为0.8399、0.4653;增设应急排风装置,进行核心生产区的气流组织优化后,排风口风速超过6 m/s时,污染物排空时间不再发生变化。结论:以排污效率作为评价指标的高生物安全风险车间的气流组织评价方法简单易行,可以用于评价并优化高生物安全风险车间的初期设计方案。
Objective To put forward an evaluation method of air distribution in the high-level biosafety containment area based on contaminant removal efficiency of pollutants.Methods The RNG k-ε turbulence model was applied to the computational fluid dynamics method for the calculation of flow field variation within the core production area,and the discrete phase model was used for the calculation of viral particulate matter,taking the core production area used for the production of novel coronavirus vaccine as an example.Discharge efficiency and emptying time were used as evaluation indexes to compare the pollutant removal effects in 2 cases of virus particulate matter emitted on the surface of the refrigerator(case 1)and emitted on the top of the isolator(case 2).Results The airflow distribution in the core production area was uniform on the whole,while small vortices existed locally;in the case of continuous distribution,the viral particles spreaded to the whole room eventually in 280 seconds;case 1 and 2 had the pollutant evacuation time being 556 and 771 s and the discharge efficiency being 0.8399 and 0.4653,respectively;the addition of emergency exhaust device and airflow organization optimization of the core production area made the pollutant evacuation time no longer change when the air speed of the exhaust outlet exceeded 6 m/s.Conclusion The evaluation method based on contaminant removal efficiency of pollutants is simple and easy to implement for air distribution,and can be used to assess and optimize the initial design plan of the high-level biosafety containment area.[Chinese Medical Equipment Journal,2022,43(3):19-23]
作者
刘智琳
孟晗
LIU Zhi-lin;MENG Han(Austar Pharmaceutical Equipment(Shijiazhuang)Ltd.,Shijiazhuang 050011,China)
出处
《医疗卫生装备》
CAS
2022年第3期19-23,共5页
Chinese Medical Equipment Journal
基金
中央引导地方科技发展资金项目(科技创新基地项目)(216Z3001G)。
关键词
高生物安全风险车间
气流组织
排污效率
数值模拟
污染物排除
high-level biosafety containment area
air distribution
contaminant removal efficiency
numerical simulation
contaminant removal
