摘要
目的探讨尤瑞克林联合丁苯酞对动脉粥样硬化性脑梗死患者血清脑源性神经营养因子(BDNF)及侧支循环的影响。方法对在河北省石家庄市人民医院接受治疗的200例动脉粥样硬化性脑梗死患者进行分析,并随机分为观察组和对照组,每组100例。对照组给予丁苯酞治疗,观察组给予丁苯肽联合丁苯酞治疗。比较2组临床疗效、日常生活能力(ADL)评分、缺血低灌注区、侧支循环脑血流量(CBF)和BDNF水平。结果治疗后,2组患者血清BDNF水平、ADL评分、CBF均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);2组缺血低灌注区面积小于治疗前,且观察组小于对照组,差异有统计学意义(P<0.05)。观察组总有效率为93.00%,高于对照组的83.00%,差异有统计学意义(P<0.05)。结论尤瑞克林联合丁苯酞治疗动脉粥样硬化性脑梗死患者疗效显著,可有效提高BDNF水平及生活能力,改善侧支循环,减少缺血低灌注区面积。
Objective To investigate the effects of urinary kallidinogenase combined with butylphthalide on serum brain-derived neurotrophic factor(BDNF)and collateral circulation in patients with atherosclerotic cerebral infarction.Methods A total of 200 patients with atherosclerotic cerebral infarction in Shijiazhuang People′s Hospital of Hebei Province were analyzed and randomly divided into observation group and control group,with 100 cases in each group.The control group was treated with butylphthalide,and the observation group was given urinary kallidinogenase combined with butylphthalide.Clinical efficacy,activities of daily living(ADL)score,ischemic hypoperfusion area,cerebral blood flow(CBF)of collateral circulation and BDNF level were compared between the two groups.Results After treatment,the serum BDNF level,ADL score and CBF of the two groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05);the ischemic hypoperfusion area in the two groups was significantly smaller than before treatment,and the observation group was significantly smaller than the control group(P<0.05);the total effective rate of the observation group was 93.00%,which was significantly higher than 83.00%of the control group(P<0.05).Conclusion Urinary kallidinogenase combined with butylphthalide has a significant therapeutic effect in patients with atherosclerotic cerebral infarction,which can effectively enhance the level of BDNF and living ability,improve collateral circulation,and reduce the area of ischemia-reperfusion area.
作者
刘惠钦
李伟峰
范月辉
孟丽
LIU Huiqin;LI Weifeng;FAN Yuehui;MENG Li(the Fourth Ward of Department of Neurology,Shijiazhuang People′s Hospital of Hebei Province,Shijiazhuang,Hebei,050000)
出处
《实用临床医药杂志》
CAS
2022年第6期43-46,共4页
Journal of Clinical Medicine in Practice
基金
河北省石家庄市科学技术研究与发展计划项目(181461043)。
关键词
丁苯酞
动脉粥样硬化
脑梗死
尤瑞克林
侧支循环
butylphthalide
atherosclerosis
cerebral infarction
urinary kallidinogenase
collateral circulation
