摘要
目的观察健脾补肾活血方治疗脑小血管病白质病变所致轻度认知功能障碍(mild cognitive impairment,MCI)的临床疗效。方法选择脾肾两虚型脑小血管病白质病变MCI患者64例为研究对象,随机分为治疗组和对照组各32例,对照组给予西医规范化治疗,治疗组在对照组治疗方案基础上加用健脾补肾活血方,治疗周期为60天。在治疗前后分别对两组患者进行MoCA量表评分、ADL量表评分、中医证候评分,并进行头颅MRI影像分级。结果两组患者治疗后MoCA量表评分、ADL量表评分、中医证候评分均较治疗前改善,而治疗组改善更明显(P<0.05)。中医证候疗效对比,治疗组有效率(86.67%)明显高于对照组(53.33%)。对比两组患者治疗后头颅MRI分级,差异无统计学意义(P>0.05)。结论健脾补肾活血方治疗脾肾两虚型脑小血管病白质病变MCI疗效明显,可有效改善患者的认知功能和日常生活活动能力,并具有可靠的安全性。
Objective To observe the clinical efficacy of Jianpi Bushen Huoxue prescription on MCI of white matter lesion in cerebral small vessel disease.Methods Sixty-four patients of MCI of white matter lesions in cerebral small vessel disease with deficiency of spleen and kidney were selected as the research objects.They were randomly divided into a treatment group and a control group of 32 cases each.The control group was given standardized treatment by Western medicine.In the treatment group,Jianpi Bushen Huoxue prescription was added on the basis of the treatment plan of the control group,the treatment period was 60 days.Before and after treatment,the MoCA scale score,ADL scale score,and TCM syndrome score were scored for the two groups of patients,and head MRI image grade was performed.Results The MoCA scale score,ADL scale score,and TCM syndrome score of the two groups of patients were improved compared with those before treatment,and the treatment group was more significant(P<0.05).Compared with the curative effect of TCM syndromes,the effective rate of the treatment group(86.67%)was significantly higher than that of the control group(53.33%).There was no significant difference in head MRI grade between the two groups after treatment(P>0.05).Conclusion Jianpi Bushen Huoxue prescription has obvious effect on MCI of white matter lesions in cerebral small vessel disease with deficiency of spleen and kidney.It can effectively improve patients’cognitive function and ability of daily living activities,and has reliable safety.
作者
马驰远
刘向哲
王新志
路永坤
王彦华
杨海燕
杨国防
MA Chi-yuan;LIU Xiang-zhe;WANG Xin-zhi;LU Yong-kun;WANG Yan-hua;YANG Hai-yan;YANG Guo-fang(First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2022年第2期400-403,共4页
Lishizhen Medicine and Materia Medica Research
基金
河南省中医药科研专项课题(2019ZY2031)
河南省中医药学科领军人才项目(预卫中医函【2021】8号)
国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者(国中医药人教函[2018]284号)。
关键词
健脾补肾活血方
脑小血管病白质病变MCI
临床疗效
Jianpi Bushen Huoxue prescription
MCI of white matter lesion in cerebral small vessel disease
Clinical efficacy
