摘要
目的探究脑钠肽(BNP)、血糖(Glu)、神经元特异性烯醇化酶(NSE)、S-100β蛋白(S-100β)联合检测在重症手足口病诊断中的价值。方法回顾性分析2017年5月至2020年5月河北医科大学附属河北省儿童医院儿科病房住院且诊断符合手足口病的100例患儿及同期健康体检的100名儿童的临床资料。依据病情严重程度将手足口病患儿分为轻症组(41例)与重症组(59例),将健康体检儿童作为对照组。比较三组BNP、Glu、NSE、S-100β水平,logistic回归分析重症手足口病的影响因素,ROC曲线分析BNP、Glu、NSE、S-100β及四项指标联合诊断重症手足口病的价值。结果重症组BNP、Glu、NSE、S-100β水平高于轻症组及对照组(P<0.05);轻症组Glu、NSE水平高于对照组(P<0.05)。BNP、Glu、NSE、S-100β为重症手足口病的独立影响因素(OR>1,P<0.05)。BNP、Glu、NSE、S-100β及四项指标联合预测重症手足口病的曲线下面积为0.815、0.880、0.639、0.910、0.914,敏感度为88.1%、83.1%、37.3%、88.1%、89.8%,特异度为61.0%、87.8%、95.1%、90.2%、90.2%。结论重症手足口病患儿BNP、Glu、NSE、S-100β水平显著高于轻症患儿及健康儿童,四项指标联合检查有利于重症手足口病患儿的早期诊断。
Objective To explore the value of combined detection of brain natriuretic peptide(BNP),glucose(Glu),neuron-specific enolase(NSE),and S-100β protein(S-100β)in severe hand,foot and mouth disease.Methods A retrospective analysis was performed on the clinical data of 100 children hospitalized and diagnosed with hand,foot and mouth disease in the Department of Emergency,Hebei Children’s Hospital Affiliated to Hebei Medical University from May 2017 to May 2020,as well as 100 children who underwent physical examination during the same period.According to severity of the disease,the children with hand,foot and mouth disease were divided into mild group(41 cases)and severe group(59 cases),and the healthy children were taken as control group.The levels of BNP,Glu,NSE,and S-100β in three groups were compared,the influencing factors of severe hand,foot and mouth disease were analyzed by logistic regression,and the value of BNP,Glu,NSE,S-100β and the four indexes combined in the diagnosis of severe hand,foot and mouth disease were analyzed by ROC curve.Results The levels of BNP,Glu,NSE,and S-100β in severe group were higher than those in mild group and control group(P<0.05);the levels of Glu and NSE in mild group were higher than those in control group(P<0.05).BNP,Glu,NSE,and S-100β were the independent influencing factors of severe hand,foot and mouth disease(P<0.05).The area under the curve of BNP,Glu,NSE,and S-100βand the four indicators combined to predict severe hand,foot and mouth disease were 0.815,0.880,0.639,0.910,0.914,and the sensitivity were 88.1%,83.1%,37.3%,88.1%,89.8%,the specificity were 61.0%,87.8%,95.1%,90.2%,90.2%.Conclusion The levels of BNP,Glu,NSE,and S-100β in children with severe hand,foot and mouth disease are significantly higher than those in mild children and healthy children.The combined examination of the four indicators is conducive to the early diagnosis of children with severe hand,foot and mouth disease.
作者
徐丽娟
郝改领
张楠
郑少敏
贾系群
张中馥
XU Lijuan;HAO Gailing;ZHANG Nan;ZHENG Shaomin;JIA Xiqun;ZHANG Zhongfu(Department of Emergency,Hebei Children’s Hospital Affiliated to Hebei Medical University,Hebei Province,Shijiazhuang 050031,China)
出处
《中国医药导报》
CAS
2022年第9期112-115,共4页
China Medical Herald
基金
河北省医学科学研究重点课题(20180622)。
关键词
脑钠肽
血糖
神经元特异性烯醇化酶
S-100Β蛋白
重症手足口病
Brain natriuretic peptide
Glucose
Neuron-specific enolase
S-100β protein
Severe hand,foot and mouth disease
