摘要
目的利用基于功能连接密度(functional connectivity density,FCD)的方法探讨伴自杀意念首发抑郁症患者静息态下半球水平功能连接模式的改变。材料与方法对前瞻性纳入的30例伴自杀意念抑郁症患者(伴自杀意念组)、28例不伴自杀意念抑郁症患者(不伴自杀意念组)及30例健康志愿者(对照组)进行汉密尔顿抑郁量表24项和Beck自杀意念量表评定,同时行功能磁共振成像扫描。计算半球间和半球内FCD,并分析伴自杀意念组差异脑区的FCD值与临床量表评分之间的关系。结果与不伴自杀意念组和对照组相比,伴自杀意念组双侧内侧前额叶的半球间FCD值降低。与对照组相比,伴自杀意念和不伴自杀意念组双侧中央后回的半球间FCD值升高,右侧中央后回和顶下小叶的半球内FCD值升高,双侧内侧前额叶的半球内FCD值降低。不伴自杀意念组左侧前扣带回的半球内FCD值较对照组降低。伴自杀意念组差异脑区的FCD值与临床量表评分无显著相关(P>0.05)。结论伴自杀意念抑郁症患者半球间及半球内FCD的改变可以反映大脑半球水平功能连接的变化,有助于更好地理解伴自杀意念的抑郁症患者大脑半球之间的相互作用。
Objective:The functional connectivity density(FCD)method was used to explore the changes of inter-and intrahemispheric functional connectivity patterns in first-episode depression patients with suicidal ideation.Materials and Methods:Thirty depression patients with suicidal ideation(SI group),28 depression patients without suicidal ideation(NSI group)and 30 healthy controls(HC group)participated in this study.Hamilton Depression scale 24-items and Beck Scale for Suicide Ideation-Chinese version were performed.All subjects underwent functional magnetic resonance imaging.The inter-and intrahemispheric FCD were calculated.Correlation analysis was performed between abnormal FCD values of SI group and clinical psychological scales.Results:Compared with NSI group and HC group,the interhemispheric FCD values decreased in bilateral medial prefrontal cortex in SI group.Compared with HC group,SI group and NSI group showed increased interhemispheric FCD values in bilateral postcentral gyrus,increased intrahemispheric FCD values in right postcentral gyrus and inferior parietal lobule,and decreased intrahemispheric FCD values in bilateral medial prefrontal cortex.Compared with HC group,NSI group showed decreased intrahemispheric FCD values in left anterior cingulate gyrus.The abnormal FCD values of SI group were not correlated with clinical psychological scales(P>0.05).Conclusions:The abnormalities of inter-and intrahemispheric FCD in depression patients with suicidal ideation can reflect the changes of functional connectivity on hemispheric level,which is helpful to better understand the interaction between hemispheres of depression patients with suicidal ideation.
作者
姜雨
程敬亮
陈苑
郑瑞平
韩少强
周冰倩
张勇
李淑英
JIANG Yu;CHENG Jingliang;CHEN Yuan;ZHENG Ruiping;HAN Shaoqiang;ZHOU Bingqian;ZHANG Yong;LI Shuying(Department of Magnetic Resonance Imaging,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第4期1-4,14,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81871327、62106229)。
关键词
抑郁症
自杀意念
功能连接密度
半球间
半球内
功能磁共振成像
depression
suicidal ideation
functional connectivity density
interhemisphere
intrahemisphere
functional magnetic resonance imaging
