血清NPY水平与子宫内膜异位症患者疼痛及焦虑、抑郁的相关性被引量：1

Correlation between serum NPY level and pain,anxiety and depression in patients with endometriosis

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摘要目的分析、探讨血清神经肽Y(NPY)表达水平与子宫内膜异位症(EMS)患者疼痛、焦虑和抑郁症状的相关性。方法采集2018年1月至2020年12月江西省人民医院病理诊断为子宫内膜异位症患者108例的血清标本和健康对照者102例的血清标本,通过酶联免疫吸附试验(Elisa法)检测血清NPY在研究组和对照组以及研究组不同疼痛程度组间的表达,同时探讨血清NPY与EMS患者焦虑、抑郁的关系。结果血清NPY在对照组中表达水平为(95.13±11.04)pg/ml,在研究组中表达水平为(147.80±21.83)pg/ml,差异有统计学意义(P<0.05);EMS患者疼痛程度越强,血清NPY水平越高,疼痛亚组间两两比较,差异均有统计学意义(P<0.05);EMS疼痛伴焦虑、抑郁者与对照组相比,血清NPY表达低,差异有统计学意义(P<0.05)。结论血清NPY在EMS患者中高表达,其水平与EMS患者疼痛程度正相关,与EMS疼痛患者焦虑、抑郁程度负相关,表明NPY可能参与EMS的发病机制,其表达与EMS机体的情感障碍、应激状态密切相关。 Objective To analyze the association between serum neuropeptide Y(NPY)expression and pain,anxiety,and depression in patients with endometriosis(EMS).Methods Serum samples were collected from 108 patients with pathologically diagnosed endometriosis and 102 healthy subjects in Jiangxi Provincial People’s Hospital from January 2018 to December 2020.The enzyme linked immunosorbent assay(Elisa)method was used to detect the expression of serum NPY in the study group,the control group and the groups with different pain levels in the study group,and the relationship between serum NPY and anxiety and depression of patients in the study group was analyzed.Results The expression level of serum NPY was[95.13±11.04]pg/ml in the control group and[147.80±21.83]pg/ml in the study group,with a statistically significant difference(P<0.05).The more severe the pain was in EMS patients,the higher the serum NPY level was,and statistically significant differences were observed between the pain subgroups(P<0.05).The expression of serum NPY in patients with EMS pain accompanied by anxiety and depression was lower,with a statistically significant difference(P<0.05).Conclusion Serum NPY is highly expressed in EMS patients,and its level is positively correlated with the degree of pain in EMS patients,but negatively correlated with anxiety and depression in EMS patients,suggesting that NPY may be involved in the occurrence and development of endometriosis,and its expression is closely related to the stress state of the body with endometriosis.

作者章永平 ZHANG Yongping(Department of Gynecology,Jiangxi Provincial People′s Hospital,the First Affiliated Hospital of Nanchang Medical College,Nanchang330006,China)

机构地区江西省人民医院南昌医学院第一附属医院妇科

出处《中国现代医生》 2022年第7期51-54,58,共5页 China Modern Doctor

基金江西省卫生健康委科技计划项目(20195048)。

关键词神经肽Y 子宫内膜异位症疼痛焦虑抑郁 Neuropeptide Y(NPY) Endometriosis(EMS) Pain Anxiety Depression

分类号 R711.71 [医药卫生—妇产科学]

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