摘要
目的 以数据挖掘方法探讨《中华医典》中治疗胃脘痛方剂的组方规律,为中医药治疗胃脘痛提供参考。方法 检索《中华医典》中所有治疗胃脘痛的有效处方,利用SAS 9.3等统计软件对药物进行因子分析与关联规则分析,挖掘高频次药物、药对、药性与归类等,并以方测法,总结用药规律。结果 共筛选处方426首,236味中药,涉及中药类别17种,其中高频药物42味,以理气药、补虚药、温里药为主,常用药对26组,强关联药物组合5个,所体现的常用治法有10类。结论 胃脘痛治疗以理气药、补虚药、温里药为主,以调理气机、益气健脾为基本治疗原则,主要治法为调畅气机、温中散寒、调和营卫、健脾益气、活血化瘀、化痰理气、健脾益气燥湿、清热化湿、疏肝解郁、行气止痛;善用陈皮、半夏、茯苓、甘草及其相互配伍,彰显“益气健脾、燥湿化痰”之功,次以半夏、香附、陈皮相互搭配凸显“疏肝、理气、化痰”之效,该研究可为胃脘痛的中医药治疗提供参考。
ObjectiveTo explore the prescription rules of treating epigastric pain in Collection of Ancient Codes and Records of Chinese Medicine by data mining method,and provide reference for the treatment of epigastric pain with traditional Chinese medicine.MethodsAll effective prescriptions for treating epigastric pain in Collection of Ancient Codes and Records of Chinese Medicine were searched,SAS 9.3 and other statistical software were used for factor analysis and association rule analysis of drugs,to discover high-frequency drugs,drug pairs,drug properties and classification, and the law of drug use from the prescriptions was further summarized.ResultsA total of426 prescriptions and 236 traditional Chinese medicines were screened out,involving 17 drug categories,including42 high-frequency drugs. The treatments mainly utilize qi regulating drugs,deficiency tonifying drugs and interiorwarming drugs. There were 26 commonly used drug pairs and 5 combinations of strongly related drugs,reflecting10 categories of commonly used treatments.ConclusionThe treatment of epigastric pain is mainly based on qi regulating drugs, deficiency tonifying drugs and interior-warming medicine. The basic treatment principle is to regulate movement of qi,replenish qi and strengthen spleen. The main treatment methods are regulating qi movement,dispersing cold by warming spleen and stomach,harmonizing ying and wei,strengthening spleen and qi,promoting blood circulation and removing blood stasis, resolving phlegm and regulating qi, eliminating dampness by strengthening spleen and qi,clearing away heat and eliminating dampness,soothing liver and relieving depression,promoting qi movement and relieving pain. Citri reticulatae pericarpium,Pinelliae rhizoma,Poria,and Glycyrrhizae radix et rhizome were mostly prescribed according to their advantages, and combined them with each other to highlight the power of“supplementing qi, strengthening spleen, eliminating dampness and resolving phlegm”. The second frequently used drugs were Pinelliae rhizoma,Cyperi rhizoma and Citri reticulatae pericarpium,and match them with each other to highlight the effect of “soothing liver,regulating qi and resolving phlegm”. This study can provide a reference for treatment of epigastric pain using the traditional Chinese medicine.
作者
龙远雄
徐寅
邓桂明
LONG Yuangxiong;XU Yin;DENG Guiming(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007 Hunan,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2022年第3期405-410,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金青年基金项目(81904176)
国家中医药管理局中医药部门公共卫生专项(2100409)
湖南省中医药科研计划重点项目(2021016)
湖南省中医药科研计划青年项目(2021162)
湖南中医药大学科研基金项目(2019XJJJ050,2019XJJJ025)。
关键词
中医药
胃脘痛
因子分析
关联规则
组方规律
益气健脾
燥湿化痰
Traditional Chinese medicine
epigastric pain
factor analysis
association rules
prescription law
supplementing qi and strengthening spleen
eliminating dampness and resolving phlegm
