摘要
目的:观察自拟柴胡栀子汤联合甲巯咪唑治疗甲状腺功能亢进症患者的效果。方法:选取84例甲状腺功能亢进症患者为研究对象,按随机数字表法分为研究组(n=42)和对照组(n=42)。对照组予以甲巯咪唑治疗,研究组在对照组基础上联合自拟柴胡栀子汤治疗,比较两组临床疗效,治疗前后中医证候积分、甲状腺激素指标[游离甲状腺素(FT_(4))、甲状腺过氧化物酶抗体(TPOAb)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.86%(39/42),高于对照组的73.81%(31/42),差异有统计学意义(P<0.05);治疗后,研究组食欲亢进、易汗等中医证候积分以及FT_(4)和TPOAb水平均低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为4.76%(2/42),低于对照组的19.05%(8/42),差异有统计学意义(P<0.05)。结论:自拟柴胡栀子汤联合甲巯咪唑治疗甲状腺功能亢进症患者可提高治疗总有效率,降低中医证候积分、甲状腺激素指标水平和不良反应发生率,效果优于单纯甲巯咪唑治疗。
Objective:To observe effects of self-made Chaihu Zhizi decoction combined with Methimazole in treatment of patients with hyperthyroidism.Methods:84 patients with hyperthyroidism were selected as the research objects and were divided into study group(n=42)and control group(n=42)according to the random number table method.The control group was treated with Methimazole,while the study group was treated with Chaihu Zhizi decoction on the basis of that of the control group.The clinical effects,the TCM syndrome score,the thyroid hormone index levels[free thyroxine(FT_(4)),thyroid peroxidase antibody(TPOAb)]and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 92.86%(39/42),which was higher than 73.81%(31/42)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the TCM syndrome scores of appetite increased,being easy to sweat and the like as well as the FT_(4) and TPOAb levels in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 4.76%(2/42),which was lower than 19.05%(8/42)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Self-made Chaihu Zhizi decoction combined with Methimazole in the treatment of the patients with hyperthyroidism can improve the total effective rate of treatment and reduce the TCM syndrome score,the thyroid hormone index levels and the incidence of adverse reactions.Moreover,it is superior to single Methimazole.
作者
韦重道
练志勋
WEI Zhongdao;LIAN Zhixun(Department of Traditional Chinese Medicine of Song County Maternal and Child Health Hospital,Luoyang 471400 Henan,China;Department of Endocrinology of Song County People’s Hospital,Luoyang 471400 Henan,China)
出处
《中国民康医学》
2022年第6期82-84,共3页
Medical Journal of Chinese People’s Health
