摘要
目的:探讨黄芪四君子汤对进展期胃癌术前辅助化疗敏感性的影响及其可能机制。方法:选取2017年1月至2018年6月在江苏省中医院消化肿瘤外科接受2个疗程术前辅助化疗的进展期胃癌患者60例,随机分为对照组(28例)和中药组(32例)。对照组仅接受辅助化疗,中药组接受辅助化疗和黄芪四君子汤治疗。应用美国癌症联合委员会肿瘤退缩分级判断化疗效果。检测患者外周血清及组织标本中IL-8表达情况,并分析化疗敏感性的影响因素。结果:中药组化疗敏感19例(59.38%),对照组化疗敏感8例(28.57%),中药组显著高于对照组(P<0.05)。手术前中药组患者IL-8水平显著低于对照组(P<0.05);中药组中化疗敏感患者胃癌组织IL-8表达水平低于化疗耐药患者。影响进展期胃癌患者化疗敏感性的因素有Lauren分型、中药辅助治疗及血清IL-8水平。结论:黄芪四君子汤可能通过降低胃癌患者外周血清IL-8水平增强术前辅助化疗敏感性。
Objective: To investigate the effects of Huangqi-Sijunzi Decoction on preoperative adjuvant chemotherapy of advanced gastric cancer and its possible mechanism. Methods: Sixty patients with advanced gastric cancer who underwent two cycles of preoperative adjuvant chemotherapy from January 2017 to June 2018 in the Department of Surgical Oncology of Jiangsu Province Hospital of Chinese Medicine, were randomly divided into two groups: control group(32 cases) and traditional Chinese medicine(TCM) group(32 cases). The control group only received adjuvant chemotherapy, while the TCM group received adjuvant chemotherapy and Huangqi-Sijunzi Decoction. The effects of preoperative adjuvant chemotherapy was determined according to tumor regression grading(TRG) of the American Joint Committee on Cancer. Detection of IL-8 expression in peripheral serum and tumor tissue specimens, and analyze the risk factors for chemosensitivity. Results: A total of 19 cases(59.38%) were sensitive to chemotherapy in TCM group and 8 cases(28.57%) in the control group(P<0.05). The level of IL-8 in TCM group was significantly lower than that in the control group before operation(P<0.05), and the expression of IL-8 of gastric cancer tissues in sensitive patients was significantly lower than that in resistant patients in TCM group. The factors affecting the chemosensitivity included Lauren classification, TCM adjuvant treatment and the serum IL-8 level. The serum IL-8 level and Lauren classification were the independent risk factors for chemosensitivity. Conclusion: Huangqi-Sijunzi Decoction may enhance the chemosensitivity by reducing the level of IL-8 in patients with advanced gastric cancer.
作者
谢贵萍
何娅妮
翟競
姚学权
沈历宗
XIE Gui-ping;HE Ya-ni;ZHAI Jing;YAO Xue-quan;SHEN Li-zong(Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2022年第3期1810-1814,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(No.81871959)
江苏省科技厅社会发展重点项目(No.BE2018758)
江苏省中医院创新发展基金专项(No.Y2018CX71)。
关键词
进展期胃癌
黄芪四君子汤
白细胞介素-8
术前辅助化疗
Advanced gastric cancer
Huangqi Sijunzi Decoction
Interleukin-8(IL-8)
Preoperative adjuvant chemotherapy
