摘要
和肽素是精氨酸血管升压素(AVP)前体分子的C末端肽,可与AVP等摩尔释放入血,半衰期约为14 d,稳定且易于检测。和肽素其特异性较低,且无器官特异性,但对急性心肌梗死(AMI)、卒中、慢性肾脏病等疾病有较高的阳性预测价值,敏感性较高。文章对和肽素在心血管疾病、肝脏疾病、肾脏疾病、呼吸系统疾病和脑卒中等疾病中的临床应用作一综述。
Copeptin is the C-terminal peptide of the precursor molecule of arginine vasopressin(AVP),which can be released into the blood equimolar with AVP by equal molar,and the half-life of it is about 14 d,which is stable and easy to detect.Copeptin has low specificity and no organ specificity,but it has high positive predictive value and high sensitivity for acute myocardial infarction(AMI),stroke,chronic kidney disease and other diseases.This review focuses on the clinical application of copeptin in cardiovascular disease,liver disease,kidney disease,respiratory disease and stroke.
作者
毛杰
卢晴晴
李萍
石盛洁
李菁
邓长娟
谭超超
谢小兵
MAO Jie;LU Qingqing;LI Ping;SHI Shengjie;LI Jing;DENG Changjuan;TAN Chaochao;XIE Xiaobing(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Department of Medical Laboratory and Pathology Center,the First Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China;Department of Clinical Laboratory,Hunan People's Hospital,Changsha 430005,Hunan,China)
出处
《检验医学》
CAS
2022年第3期291-294,共4页
Laboratory Medicine
关键词
和肽素
心脑血管疾病
肝脏疾病
肾脏疾病
呼吸系统疾病
Copeptin
Cardiovascular and cerebrovascular diseases
Liver disease
Kidney disease
Respiratory disease
