摘要
经颅磁声电刺激是一种新型无创的神经调控手段,其利用超声与静磁场耦合作用产生的感应电场调节相应脑区神经节律振荡活动。本文旨在探讨经颅磁声电刺激对记忆过程中神经元集群信息传递与交流的影响。实验中,将20只健康成年维斯塔尔(Wistar)大鼠随机分为对照组(5只)和刺激组(15只),对刺激组施加0.05~0.15 T、2.66~13.33 W/cm2的经颅磁声电刺激,对照组不施加刺激;采集大鼠执行T迷宫工作记忆任务中前额叶皮层的局部场电位信号,比较不同参数刺激组大鼠与对照组大鼠delta节律相位、theta节律相位与gamma节律幅值之间的耦合差异性。实验结果显示,刺激组delta节律与gamma节律的耦合强度明显低于对照组(P<0.05),theta节律与gamma节律的耦合强度明显高于对照组(P<0.05);随着刺激参数的增加,delta节律与gamma节律、theta节律与gamma节律耦合程度分别呈现减小、增大的趋势。本文初步研究结果表明,经颅磁声电刺激能够抑制前额叶皮层中delta节律神经活动,增强theta节律与gamma节律振荡活动,从而促进了不同空间范围内神经元集群之间的信息交流与传递,这为进一步探索经颅磁声电刺激调节大脑记忆功能的作用机制奠定了基础。
Transcranial magneto-acoustic-electrical stimulation is a new non-invasive neuromodulation technology, in which the induced electric field generated by the coupling effect of ultrasound and static magnetic field are used to regulate the neural rhythm oscillation activity in the corresponding brain region. The purpose of this paper is to investigate the effects of transcranial magneto-acoustic-electrical stimulation on the information transfer and communication in neuronal clusters during memory. In the experiment, twenty healthy adult Wistar rats were randomly divided into a control group(five rats) and stimulation groups(fifteen rats). Transcranial magneto-acoustic-electrical stimulation of 0.05~0.15 T and 2.66~13.33 W/cm2 was applied to the rats in stimulation groups, and no stimulation was applied to the rats in the control group. The local field potentials signals in the prefrontal cortex of rats during the T-maze working memory tasks were acquired. Then the coupling differences between delta rhythm phase, theta rhythm phase and gamma rhythm amplitude of rats in different parameter stimulation groups and control group were compared. The experimental results showed that the coupling intensity of delta and gamma rhythm in stimulation groups was significantly lower than that in the control group(P<0.05), while the coupling intensity of theta and gamma rhythm was significantly higher than that in the control group(P<0.05). With the increase of stimulation parameters, the degree of coupling between delta and gamma rhythm showed a decreasing trend, while the degree of coupling between theta and gamma rhythm tended to increase. The preliminary results of this paper indicated that transcranial magneto-acousticelectrical stimulation inhibited delta rhythmic neuronal activity and enhanced the oscillation of theta and gamma rhythm in the prefrontal cortex, thus promoted the exchange and transmission of information between neuronal clusters in different spatial scales. This lays the foundation for further exploring the mechanism of transcranial magneto-acousticelectrical stimulation in regulating brain memory function.
作者
党君武
张帅
由胜男
杜文静
徐桂芝
DANG Junwu;ZHANG Shuai;YOU Shengnan;DU Wenjing;XU Guizhi(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130,P.R.China;Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health,Hebei University of Technology,Tianjin 300130,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2022年第2期267-275,共9页
Journal of Biomedical Engineering
基金
国家自然科学基金面上项目(51877069)
河北省自然科学基金面上项目(E2021202184)。
关键词
经颅磁声电刺激
工作记忆
前额叶皮层
局部场电位
相位幅值耦合
Transcranial magneto-acoustic-electrical stimulation
Working memory
Prefrontal cortex
local field potentials
Phase amplitude coupling
