摘要
目的:分析惠东地区腹泻患者沙门菌属血清型感染现状与多重耐药谱特点,为制订防治措施和指导临床用药提供参考。方法:收集2018年—2020年医院诊治的腹泻患者955例粪便样本的细菌培养结果,分析分离出的沙门菌属的血清学分型和耐药情况。结果:955例腹泻患者粪便样本中,检出沙门菌属61株,并在其中分离出12种血清型(以鼠伤寒沙门菌和肠炎沙门菌为主,分别占34.43%和24.59%);药敏结果显示,沙门菌属对氨苄西林、四环素、氯霉素的耐药率分别为88.52%、72.13%和55.74%,其对第3代头孢菌素的敏感率约为73.00%,对喹诺酮类的敏感率约为95.00%,对碳青霉烯类敏感率达100.00%。对3种以上抗菌药物耐药的沙门菌属菌株有34株,多重耐药率达55.74%。结论:惠东地区腹泻患者沙门菌属感染血清型以鼠伤寒型和肠炎型为主,且耐药性较强,多重耐药现象较为严重,应积极开展耐药监测和防治对策,以指导临床科学用药。
Objective:To analyze the serotypes and drug resistance of Salmonella in patients with diarrhea in Huidong area so as to provide reference for formulating prevention and treatment measures and guiding clinical medication.Methods:The bacterial culture results of stool samples from 955 patients with diarrhea diagnosed and treated in hospitals from 2018 to 2020 were collected,and the serotypes and drug resistance of Salmonella isolates were analyzed.Results:A total of 61 strains of Salmonella were detected in the stool samples from 955 patients with diarrhea,and 12 serotypes were isolated(Salmonella typhimurium and Salmonella enteritidis were the main serotypes,accounting for 34.43% and 24.59%,respectively).The drug sensitivity results showed that the drug resistance rates of Salmonella to ampicillin,tetracycline and chloramphenicol were 88.52%,72.13% and 55.74%,respectively.The sensitivity rates of Salmonella to the third generation cephalosporins were about 73.00%,to quinolones were about 95.00%,to carbapenem was 100.00%.There were 34 strains of Salmonella resistant to more than 3 kinds of antibacterials,and the multi-drug resistance rate was 55.74%.Conclusion:The serotypes of Salmonella in diarrhea patients in Huidong area are mainly typhus and enteritis which have strong drug resistance and serious multi-drug resistance.Therefore,drug resistance monitoring and prevention and treatment countermeasures should be actively carried out to guide clinical scientific drug use.
作者
温应铭
张丹
古丽红
赖志坚
WEN Ying-ming;ZHANG Dan;GU Li-hong;LAI Zhi-jian(Huidong County Center for Disease Control and Prevention,Huidong Guangdong 516300,China;Huidong County People's Hospital,Huidong Guangdong 516300,China)
出处
《抗感染药学》
2022年第1期116-119,共4页
Anti-infection Pharmacy
关键词
腹泻
沙门菌
血清型
耐药性
diarrhea
Salmonella
serotype
drug resistance
