摘要
目的:分析1例阿奇霉素致患者血尿的关联性与可能机制,为临床治疗该类病例提供参考。方法:通过1例重症肺炎患者使用阿奇霉素致血尿的病历资料,结合文献报道的相似病例,对此类患者的一般情况、原患疾病、药物治疗过程等进行分析,探讨阿奇霉素致血尿的病例特征、发生机制、处理和转归。结果:阿奇霉素相关性血尿多为肉眼可见血尿,可发生在用药后40 min至4 d,停用阿奇霉素及对症治疗后血尿症状好转;阿奇霉素相关性血尿发生可能与阿奇霉素引起肾损伤有关。结论:阿奇霉素是临床上常用的抗菌药物,尽管关于其所致血尿的文献报道较少,临床在用药过程中仍需谨慎;当患者出现血尿时,应立即停用阿奇霉素,必要时采取对症处理措施。
Objective:To analyze the correlation between azithromycin and hematuria and its possible mechanism so as to provide reference for the clinical treatment of similar patients.Methods:Based on the data of a severe pneumonia patient with azithromycin induced hematuria,and combined with similar cases reported in the literature,the general situation,primary disease and drug treatment process of such patients were analyzed.The characteristics,pathogenesis,management and outcome of azithromycin induced hematuria were discussed.Results:Azithromycin associated hematuria was mostly visible to the naked eye,which could occur from 40 min to 4 d after administration.The symptoms of hematuria were improved after stopping azithromycin and symptomatic treatment.Azithromycin-associated hematuria might be related to kidney injury caused by azithromycin.Conclusion:Azithromycin is a commonly used antibacterial agent in clinical practice.Although there are few literature reports on hematuria caused by azithromycin,it is still necessary to be cautious in clinical usage.When the patient has hematuria,azithromycin should be stopped immediately,and symptomatic measures should be taken if necessary.
作者
张宝
赵珊
杨红
马晓
田洪星
李悦
ZHANG Bao;ZHAO Shan;YANG Hong;MA Xiao;TIAN Hong-xing;LI Yue(Department of Pharmacy,Guiyang Maternal and Child Healthcare Hospital,Guiyang 550003,China)
出处
《抗感染药学》
2022年第1期130-132,158,共4页
Anti-infection Pharmacy
关键词
阿奇霉素
血尿
抗菌药物
药物不良反应
azithromycin
hematuria
antibacterial agent
adverse drug reaction
