摘要
目的:探讨氨甲环酸联合全膝关节置换术(TKA)治疗膝关节骨性关节炎(KOA)的临床效果。方法:选取2019年8月-2021年5月阳春市中医院收治的80例接受手术治疗的KOA患者,将其随机分为研究组(40例)与对照组(40例)。对照组接受常规TKA手术治疗,研究组接受TKA联合氨甲环酸治疗。对比两组手术相关指标、疼痛视觉模拟评分法(VAS)评分、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、Fugl-Meyer评定量表(FMA)评分及并发症发生情况。结果:研究组术后引流量、术中出血量均少于对照组,术后住院时间短于对照组(P<0.05);术前,两组TNF-α、CRP水平及FMA-下肢评分比较,差异均无统计学意义(P>0.05),术后7 d,研究组TNF-α、CRP均低于对照组(P<0.05),术后3个月,研究组FMA-下肢评分高于对照组(P<0.05)。术后1、2、48 h,两组的VAS评分比较,差异均无统计学意义(P>0.05),术后3、24 h,研究组的VAS评分均低于对照组(P<0.05);术后3个月研究组并发症发生率为5.00%,低于对照组的20.00%(P<0.05)。结论:氨甲环酸联合TKA手术治疗KOA的效果确切,不仅可以有效减少患者术中出血量、缩短患者住院时间,还能降低患者术后感染风险及疼痛感,促进患者运动功能的恢复。
Objective:To investigate the clinical efficacy of Tranexamic Acid combined with total knee arthroplasty (TKA) in the treatment of knee osteoarthritis (KOA).Method:A total of 80 patients with KOA who received surgical treatment in Yangchun Hospital of Traditional Chinese Medicine from August 2019 to May 2021 were randomly divided into study group (40 cases) and control group (40 cases).The control group received conventional TKA surgical treatment,and the study group received TKA combined with Tranexamic Acid.The operation related indexes,pain visual analogue scale (VAS) score,tumor necrosis factorα (TNF-α),C-reactive protein (CRP),Fugl-Meyer rating scale (FMA) score and complications were compared between the two groups.Result:The postoperative drainage volume and intraoperative blood loss in the study group were less than those in the control group,and the postoperative hospital stay was shorter than that in the control group (P<0.05);there were no significant differences in the levels of TNF-α and CRP,the scores of FMA-lower limbs between the two groups before operation (P>0.05),7 d after operation,the TNF-α and CRP in the study group were lower than those in the control group (P<0.05),3 months after operation,the FMA-lower limb score of the study group was higher than that of the control group (P<0.05).There were no significant differences in VAS score between the two groups at 1,2 and 48 h after operation (P>0.05),the VAS scores of the study group were lower than those of the control group at 3 and 24 h after operation (P<0.05);3 months after operation,the incidence of complications in the study group was 5.00%,which was lower than 20.00% in the control group (P<0.05).Conclusion:Tranexamic Acid combined with TKA is effective in the treatment of KOA,it can not only effectively reduce the intraoperative blood loss and shorten the hospital stay,but also reduce the risk of postoperative infection and pain,and promote the recovery of motor function.
作者
谢宝林
邱春云
麦灿
陈品伟
XIE Baolin;QIU Chunyun;MAI Can;CHEN Pinwei(Yangchun Hospital of Traditional Chinese Medicine,Guangdong Province,Yangchun 529600,China;不详)
出处
《中国医学创新》
CAS
2022年第12期108-112,共5页
Medical Innovation of China
基金
广东省中医药管理局项目(20202244)。
