摘要
目的:探究及观察帕罗西汀在帕金森合并抑郁患者中的疗效及对脑血流灌注的影响。方法:选取2019年7月-2021年6月东台市第三人民医院收治的80例帕金森合并抑郁患者为研究对象,根据随机数字表法分为常规治疗组(对照组)和常规治疗加帕罗西汀组(观察组),每组40例。比较两组疗效、治疗前后的帕金森综合评分量表(UPDRS)、汉密尔顿抑郁量表(HMAD)评分及脑血流灌注指标。结果:观察组治疗4、8周总有效率均显著高于对照组(P<0.05)。治疗前,两组UPDRS评分、脑血流灌注指标比较,差异均无统计学意义(P>0.05);治疗4、8周,两组UPDRS评分均低于治疗前,脑血流灌注指标均高于治疗前,且观察组均优于对照组,差异均有统计学意义(P<0.05)。两组治疗前HAMD评分情况比较,差异无统计学意义(P>0.05);观察组治疗4、8周HAMD评分情况均优于对照组,差异均有统计学意义(P<0.05)。结论:帕罗西汀在帕金森合并抑郁患者中的疗效较好,且可有效改善患者的脑血流灌注,在帕金森合并抑郁患者中的应用价值较高。
Objective:To investigate and observe the effect of Paroxetine in patients with Parkinson disease complicated with depression and its influence on cerebral blood perfusion.Method:A total of 80 patients with Parkinson disease complicated with depression admitted to Dongtai Third People’s Hospital from July 2019 to June 2021 were chosen for the study,and they were divided into routine treatment group (the control group) and routine treatment and Paroxetine group (the observation group) according to the method of random number table,40 cases in each group.Then the curative effect,unified Parkinson disease rating scale (UPDRS),Hamilton depression scale (HMAD scale) and cerebral blood perfusion indexes before and after treatment of two groups were compared.Result:The total effective rates of the observation group at 4 and 8 weeks after treatment were significantly higher than those of the control group (P<0.05).Before treatment,the UPDRS scores and cerebral blood perfusion indexes of two groups were compared,the differences were not statistically significant (P>0.05).At 4 and 8 weeks after treatment,the UPDRS scores of two groups were significantly lower than those before treatment,and the cerebral blood perfusion indexes were significantly higher than those before treatment,and the observation group were significantly better than those of the control group,the differences were statistically significant (P<0.05).The HMAD scores of two groups before treatment were compared,the differences were not statistically significant (P>0.05);the HMAD scores of the observation group at 4 and 8 weeks after treatment were significantly better than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The effect of Paroxetine in patients with Parkinson disease complicated with depression is better,and it can effectively improve the cerebral blood perfusion of patients,so its application value in patients with Parkinson disease complicated with depression is higher.
作者
刘明官
LIU Mingguan(Dongtai Third People’s Hospital,Jiangsu Province,Dongtai 224226,China)
出处
《中国医学创新》
CAS
2022年第11期157-161,共5页
Medical Innovation of China
关键词
帕罗西汀
帕金森
抑郁
脑血流灌注
Paroxetine
Parkinson disease
Depression
Cerebral blood perfusion
