摘要
目的:研究肺楔形切除术治疗早期老年非小细胞肺癌(NSCLC)患者的效果及对炎症反应、应激指标的影响。方法:将2019年5月-2021年5月朝阳市中心医院收治的150例早期老年NSCLC患者纳入研究,将其以电脑随机数字表法分为研究组与常规组,每组75例。常规组开展肺叶切除术治疗,研究组开展肺楔形切除术。对比两组各项手术指标,治疗前后血清炎症反应及应激指标水平变化情况,术后并发症发生情况。结果:研究组手术时长、术中失血量、术后引流量及住院时间均优于常规组(P<0.05)。研究组术后血清白细胞介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平均低于常规组(P<0.05)。研究组术后血清P物质(SP)、前列腺素E_(2)(PGE_(2))水平均低于常规组,而缓激肽(BK)水平高于常规组(P<0.05)。两组术后感染、胸腔积液及支气管胸膜瘘发生率比较,差异均无统计学意义(P>0.05)。结论:肺楔形切除术治疗早期老年NSCLC患者的效果较佳,可显著改善炎症反应及应激指标水平,且不会增加术后并发症发生风险。
Objective:To study the effect of of wedge resection of lung in the treatment of elderly patients with early non-small cell lung cancer (NSCLC) and its influence on inflammatory response,stress index.Method:A total of 150 elderly patients with early NSCLC admitted to the Central Hospital of Chaoyang City from May 2019 to May 2021 were included in the study.They were divided into the study group and the routine group by computer random number table,75 cases in each group.Lobectomy was performed in the routine group and wedge resection of lung was performed in the study group.The each operation indexes,serum inflammatory response and stress index level changes before and after treatment,postoperative complications of two groups were compared.Result:The duration of operation,intraoperative blood loss,postoperative drainage flow and hospital stay in the study group were better than those in the routine group (P<0.05).The serum levels of interleukin-6 (IL-6),C reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in the study group after operation were lower than those in the routine group (P<0.05).The serum levels of substance P (SP) and prostaglandin E_(2)(PGE_(2)) in the study group were lower than those in the routine group,while the serum levels of bradykinin (BK) in the study group after operation were higher than those in the routine group (P<0.05).There were no significant differences in the incidence of postoperative infection,pleural effusion and bronchopleural fistula between two groups (P>0.05).Conclusion:Wedge resection of lung has a good efficacy in the treatment of elderly patients with NSCLC,it can significantly improve the levels of inflammatory response and stress indicators,and does not increase the risk of postoperative complications.
作者
鲍杰
BAO Jie(The Central Hospital of Chaoyang City,Liaoning Province,Chaoyang 122000,China)
出处
《中国医学创新》
CAS
2022年第8期28-31,共4页
Medical Innovation of China
关键词
非小细胞肺癌
肺楔形切除术
炎症反应
应激指标
Non-small cell lung cancer
Wedge resection of lung
Inflammatory response
Stress index
