摘要
目的探讨补肾填精方对阴虚火旺型围绝经期综合征(PMS)患者促卵泡激素(FSH)、促黄体生成素(LH)、血清雌二醇(E;)水平的影响。方法纳入2019年10月—2020年10月医院妇科门诊收治的57例PMS患者,按照就诊先后顺序,随机分为两组,即治疗组29例和对照组28例。其中治疗组给予补肾填精方治疗,对照组给予坤泰胶囊治疗。12周为一个疗程。治疗前后分别测定受试者一般情况;中医证候积分;Kupperman评分;性激素水平、血脂水平。结果治疗后,治疗组中医证候积分低于对照组(P<0.05);治疗后治疗组Kupperman低于对照组(P<0.05);治疗后,两组患者治疗后FSH及LH水平较治疗前显著下降,且治疗组较对照组下降明显(P<0.05);治疗后,治疗组与对照组HDL水平较治疗前均上升,且治疗组较对照组上升明显(P<0.05);治疗后,治疗组和对照组TC、TG、LDL水平较治疗前均有下降,且治疗组较对照组下降明显(P<0.05)。结论补肾填精方能良好改善血清内性激素及血脂水平,且安全性较高,具有较好的临床应用价值。
Objective To explore the effect of Bushen Tianjin Recipe(补肾填精方)on the levels of follicle-stimulating hor⁃mone(FSH),luteinizing hormone(LH)and serum estradiol(E2)in patients with perimenopausal syndrome(PMS)of Yin defi⁃ciency and fire hyperactivity type.Methods A total of 57 patients with PMS who were admitted to the gynecological clinic of the hospital from October 2019 to October 2020 were randomly divided into two groups,namely,29 cases in the treatment group and 28 cases in the control group.The treatment group was treated with Bushen Tianjin Recipe,and the control group was treated with Kuntai Capsule(坤泰胶囊).Twelve weeks was a course of treatment.The general conditions of the subjects were measured be⁃fore and after treatment.TCM syndrome score,Kupperman score,sex hormone levels and blood lipid levels were compared.Re⁃sults After treatment,the scores of TCM syndromes in the treatment group were lower than those in the control group(P<0.05).Kupperman in the treatment group was lower than that in the control group(P<0.05).After treatment,the levels of FSH and LH in the two groups were significantly lower than those before treatment and the levels of the treatment group were decreased signifi⁃cantly compared with those of the control group(P<0.05).After treatment,the HDL levels of the treatment group and the con⁃trol group were increased compared with those before treatment,and the treatment group′s level was significantly increased com⁃pared with that of the control group(P<0.05).After treatment,the levels of TC,TG and LDL in the treatment group and the control group were decreased compared with those before treatment,and the treatment group′s levels were decreased significantly compared with those of the control group(P<0.05).Conclusion Bushen Tianjin Recipe can improve the serum levels of sex hor⁃mones and blood lipids,and has high safety and good clinical application value.
作者
李勇
李彩杰
郑录欣
LI Yong;LI Caijie;ZHENG Luxin(First Affiliated Hospital of Henan University,Zhengzhou 475000,Henan,China)
出处
《实用中医内科杂志》
2022年第2期109-112,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
河南省医学科技攻关计划(2018020320)。
关键词
补肾填精方
阴虚火旺
围绝经期综合征
促卵泡激素
促黄体生成素
雌二醇
中医证候积分
Bushen Tianjin Recipe(补肾填精方)
Yin deficiency and fire hyperactivity
perimenopausal syndrome
follicle stimulating hormone
luteinizing hormone
estradiol
TCM syndrome score
