摘要
目的观察氯氮平联合阿立哌唑、利培酮治疗难治性精神分裂症的临床疗效对比及对患者糖脂代谢水平的影响。方法选取2019年5月-2020年5月在我院诊治的46例难治性精神分裂症患者为研究对象,采用随机数字表法分为对照组和观察组,各23例。对照组采用氯氮平联合利培酮治疗,观察组采用氯氮平联合阿立哌唑治疗,比较两组治疗总有效率、阳性症状与阴性症状评分(PANSS)、认知功能评分、空腹血糖、餐后2h血糖、血脂指标、不良反应发生率。结果观察组治疗总有效率为91.30%,高于对照组的82.61%(P<0.05);两组PANSS评分均低于治疗前,且观察组低于对照组(P<0.05);两组认知功能评分均高于治疗前,且观察组高于对照组(P<0.05);两组空腹血糖、餐后2h血糖均高于治疗前,但观察组低于对照组(P<0.05);两组血清总胆固醇(TC)与三酰甘油(TG)均高于治疗前,但观察组低于对照组(P<0.05);观察组不良反应发生率为8.70%,低于对照组的21.74%(P<0.05)。结论氯氮平联合阿立哌唑难治性精神分裂症的临床疗效理想,总有效率高,可降低阳性症状与阴性症状评分,提高认知功能评分,且对糖脂代谢指标影响较小,不良反应少。
Objective To observe the clinical efficacy of clozapine combined with aripiprazole and risperidone in the treatment of treatment resistant sehizophrenia and its effect on glucose and lipid metabolism.Methods A total of 46 patients with treatment resistant sehizophrenia treated in our hospital from May 2019 to May 2020 were selected and randomly divided into control group and observation group,with 23 cases in each group.The control group was treated with clozapine combined with risperidone,and the observation group was treated with clozapine combined with aripiprazole.The total effective rate,positive and negative symptom score(PANSS),cognitive function score,fasting blood glucose,postprandial 2 h blood glucose,blood lipid index and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.30%,which was higher than 82.61%of the control group(P<0.05).The PANSS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The cognitive function scores of the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).The fasting blood glucose and postprandial 2 h blood glucose in the two groups were higher than those before treatment,but those in the observation group were lower than those in the control group(P<0.05).The serum total cholesterol(TC)and triglyceride(TG)in the two groups were higher than those before treatment,but the observation group was lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.70%,which was lower than 21.74%in the control group(P<0.05).Conclusion The clinical efficacy of clozapine combined with aripiprazole in treatment resistant sehizophrenia is ideal,and the total effective rate is high.It can reduce the scores of positive and negative symptoms,and improve the cognitive function score.It has little effect on glucose and lipid metabolism indexes,and few adverse reactions.
作者
廖鸿钊
钟建辉
LIAO Hong-zhao;ZHONG Jian-hui(Department of Psychiatry,Xingguo County Second Hospital,Xingguo 342400,Jiangxi,China)
出处
《医学信息》
2022年第9期141-143,共3页
Journal of Medical Information
关键词
氯氮平
阿立哌唑
利培酮
难治性精神分裂症
糖脂代谢
Clozapine
Aripiprazole
Risperidone
Treatment resistant sehizophrenia
Glucose and lipid metabolism
