摘要
目的:探讨替吉奥联合三维适形放射对中晚期食管癌患者炎症因子水平及预后的影响。方法:选取随州市曾都医院2018年1月-2020年5月收治的80例中晚期食管癌患者,按照随机数字表法分为对照组(40例)和观察组(40例)。两组均给予对症及三维适形放射治疗,在此基础上,对照组联合氟尿嘧啶+奈达铂,观察组联合给予替吉奥胶囊。治疗3个疗程并随访1年,比较两组临床疗效、治疗前后血清炎症因子、实验室指标水平及生存质量。结果:治疗后,观察组总有效率高于对照组(P<0.05)。与治疗前比较,治疗后两组血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、血管内皮生长因子(VEGF)、糖类抗原CA125、CA199和癌胚抗原(CEA)水平均降低,且观察组低于对照组(P<0.05)。随访后,两组生命质量测量表(QLQ-C30)各项评分均升高,且观察组高于对照组(P<0.05)。结论:替吉奥联合三维适形放射可缓解中晚期食管癌患者临床症状,降低肿瘤标志物水平,抑制炎症反应,提高生存质量。
Objective:To investigate the effect of Tegafur,Gimeracil and Oteracil Potassium combined with three-dimensional conformal radiation on the levels of inflammatory factors and the prognosis in patients with moderately advanced esophageal cancer.Method:Eighty patients with moderately advanced esophageal cancer treated in Suizhou Zengdu Hospital from January 2018 to May 2020 were selected and divided into the control group(40 cases)and the observation group(40 cases)according to the random number table method.Both groups were given symptomatic and three-dimensional conformal radiation therapy.On this basis,the control group was given Fluorouracil+Nedaplatin,and the observation group was given Tegafur,Gimeracil and Oteracil Potassium Capsule.After three courses of treatment and one-year follow-up,the clinical efficacy,serum inflammatory factors,laboratory index levels,and quality of life were compared between the two groups.Result:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).Compared with those before treatment,the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin(IL-8),vascular endothelial growth factor(VEGF),carbohydrate antigen CA125,CA199 and carcinoembryonic antigen(CEA)in the two groups decreased after treatment,and the levels in the observation group were lower than those in the control group(P<0.05).After follow-up,the life quality meter(QLQ-C30)scores of the two groups all increased than before treatment,and the scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The combination of Tegafur,Gimeracil and Oteracil Potassium and three-dimensional conformal radiation can relieve the clinical symptoms,reduce the levels of tumor markers,inhibit the inflammatory response,and improve the quality of survival in patients with moderately advanced esophageal cancer.
作者
蒋知强
朱勇
邹媛媛
JIANG Zhiqiang;ZHU Yong;ZOU Yuanyuan(Suizhou Zengdu Hospital,Suizhou 441300,China;不详)
出处
《中外医学研究》
2022年第10期59-62,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
中晚期食管癌
替吉奥
三维适形放射治疗
肿瘤标志物
Moderately advanced esophageal cancer
Tegafur
Gimeracil and Oteracil Potassium
Three-dimensional conformal radiation
Tumor markers
