摘要
目的:探究不同术式治疗脑出血的安全性及其对神经功能、炎性反应的影响。方法:回顾性分析2018年1月-2019年12月广州医科大学附属惠州医院收治的92例脑出血患者的病历资料。根据治疗差异分为观察组和对照组,各46例。两组术前均予以相关干预,对照组实施开颅血肿清除术治疗,观察组实施微创颅内抽吸术治疗。比较两组术前、术后炎性反应,术前及术后2周神经功能、日常生活能力及安全性。结果:术后,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平均提高,观察组CRP、TNF-α、IL-6、IL-8水平均低于对照组(P<0.05)。术后2周,两组美国国立卫生研究院卒中量表(NIHSS)评分均降低,日常生活能力评分表(ADL)评分均升高,观察组NIHSS评分低于对照组,ADL评分高于对照组(P<0.05)。观察组并发症发生率低于对照组(P<0.05)。结论:微创颅内抽吸术治疗脑出血患者可进一步降低机体应激性,稳定炎性反应,提升神经功能及日常生活能力,具备较高安全性,临床应用价值较高。
Objective:To explore the safety of different surgery in the treatment of cerebral hemorrhage and its influence on nerve function and inflammatory reaction.Method:The medical records of 92 patients with cerebral hemorrhage admitted to Huizhou Third People’s Hospital from January 2018 to December 2019 were retrospectively analyzed.According to the treatment difference,they were divided into observation group and control group,46 cases in each group.Both groups were given the preoperative related intervention,the control group was treated with craniotomy hematoma removal surgery,and the observation group was treated with minimally invasive intracranial aspiration surgery.Preoperative and postoperative inflammatory reaction,neurological function,daily living ability before and 2 weeks after surgery and safety were compared between the two groups.Result:After surgery,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in the two groups were increased,and the levels of CRP,TNF-α,IL-6 and IL-8 in observation group were lower than those in control group(P<0.05).Two weeks after surgery,National Institutes of Health stroke scale(NIHSS)scores of both groups decreased,activity of daily living scale(ADL)scores of both groups increased,NIHSS scores of observation group was lower than that of control group,ADL scores was higher than that of control group(P<0.05).The incidence of complication of observation group was lower than that of control group(P<0.05).Conclusion:The minimally invasive intracranial aspiration surgery in the treatment of patients with cerebral hemorrhage can further reduce the body’s stress,stabilize the inflammatory reaction,improve the nerve function and the ability of daily living,with high safety and high clinical application value.
作者
张立阳
胡永珍
余同英
ZHANG Liyang;HU Yongzhen;YU Tongying(Huizhou Hospital of Guangzhou Medical University,Huizhou 516000,China;不详)
出处
《中外医学研究》
2022年第11期54-57,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广东省医学科学技术研究基金项目(A2018529)。
关键词
开颅血肿清除术
微创颅内抽吸术
脑出血
炎性反应
神经功能
Craniotomy hematoma removal surgery
Minimally invasive intracranial aspiration surgery
Cerebral hemorrhage
Inflammatory reaction
Nerve function
