摘要
目的:比较氯吡格雷和替格瑞洛对老年冠心病(CHD)患者经皮冠状动脉介入(PCI)术后血小板功能、炎性反应及主要不良心血管事件(MACE)的影响。方法:采用回顾性分析方法,抽取2019年3月-2020年8月在我院实施PCI术的100例老年CHD患者信息,根据药物治疗方式分组,给予替格瑞洛联合阿司匹林的患者为观察组,给予氯吡格雷联合阿司匹林的患者为对照组。比较治疗前后两组的最大血小板聚集率(MPAR)、P2Y12反应单位(PRU)、IL-6、TNF-α、CRP、出血事件、主要不良心血管事件以及不良反应。结果:治疗后两组的MPAR、PRU、IL-6、TNF-α及CRP水平均较治疗前明显降低(P<0.05),观察组上述指标均明显低于对照组(P<0.05);观察组MACE发生率为20.00%,明显低于对照组(38.00%),P<0.05。两组不良反应发生率及出血事件无显著性差异(P>0.05)。结论:替格瑞洛与氯吡格雷均能够明显改善老年CHD患者PCI术后的血小板功能,降低炎性反应及MACE发生率,但替格瑞洛的效果优于氯吡格雷。
Objective:To compare the effects of clopidogrel and ticagrelor on platelet function,inflammatory response and major adverse cardiovascular events(MACE)in elderly patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:100 elderly CHD patients who underwent PCI in our hospital from March 2019 to August 2020 were retrospectively enrolled in this study and were divided into groups according to drug treatment.The observation group was treated with ticagrelor and aspirin,and the control group was treated with clopidogrel and aspirin.The maximum platelet aggregation rate(MPAR),P2Y12 response unit(PRU),IL-6,TNF-α,CRP,bleeding events,MACE,and adverse drug reaction(ADR)before and after treatment were compared between the two groups.Results:The MPAR,PRU,IL-6,TNF-α,and CRP in the two groups were all significantly decreased after treatment(P<0.05),among which the above indexes of the observation group were significantly lower than those of the control group(P<0.05).The incidence of MACE in the observation group(20.00%)was significantly lower than that of the control group(38.00%),P<0.05.There were no significant differences in the incidence of ADR and blood events between the two groups(P>0.05).Conclusion:Both ticagrelor and clopidogrel could significantly improve the platelet function,reduce the inflammatory response and incidence of MACE after PCI in elderly CHD patients,while ticagrelor was superior to clopidogrel.
作者
袁勇程
刘尚军
YUAN Yong-cheng;LIU Shang-jun(Department of Cardiology,Sanya Central Hospital/the Third People's Hospital of Hainan,Sanya 572000,China)
出处
《中国药物应用与监测》
CAS
2022年第2期72-75,共4页
Chinese Journal of Drug Application and Monitoring
基金
海南省卫生健康行业科研项目(20A200540)。
关键词
冠心病
老年
经皮冠状动脉介入术
替格瑞洛
氯吡格雷
血小板功能
Coronary heart disease
Elderly
Percutaneous coronary intervention
Ticagrelor
Clopidogrel
Platelet function
