摘要
目的探讨平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、红细胞分布宽度变异系数(RDW-CV)和血红蛋白A2(HbA2)筛查αβ复合型珠蛋白生成障碍性贫血(简称地贫)的价值。方法选取2014年1月至2020年12月于该院门诊就诊和住院的αβ复合型地贫患者97例为研究对象,根据表型不同分为静止型αβ复合型地贫组38例,轻型αβ复合型地贫组49例,中间型αβ复合型地贫组10例。另选取健康体检者90例作为对照组。检测研究对象MCV、MCH、RDW-CV,进行血红蛋白电泳检测HbA2。采用受试者工作特征曲线评估MCV、MCH、RDW-CV和HbA2对αβ复合型地贫的诊断效能。结果与对照组比较,静止型、轻型、中间型αβ复合型地贫组MCV、MCH均降低,RDW-CV和HbA2均升高,差异有统计学意义(P<0.05)。与中间型αβ复合型地贫组比较,静止型、轻型αβ复合型地贫组MCV、MCH、HbA2均升高,RDW-CV均降低,差异有统计学意义(P<0.05)。MCV、MCH、RDW-C V和HbA2诊断αβ复合型地贫的截断值分别为78.8 fL、26.65 pg、14.15%和3.50%,曲线下面积分别为0.978、0.989、0.959、0.999。结论MCV、MCH、RDW-CV和HbA2对αβ复合型地贫有一定的诊断价值,其中以HbA2的效能最高,可用于αβ复合型地贫的筛查。
Objective To investigate the value of mean corpuscular volume(MCV),mean corpuscular hemoglobin content(MCH),coefficient of variation of red blood cell distribution width(RDW-CV)and hemoglobin A2(HbA2)in screening αβ complex thalassemia.Methods A total of 97 patients with αβ complex thalassemia who were treated and hospitalized in the hospital from January 2014 to December 2020 were selected as the research objects.According to the different phenotypes,they were divided into 38 cases of resting αβ complex thalassemia group,49 cases of mild αβ complex thalassemia group,and 10 cases of intermediate αβ complex thalassemia group.Another 90 healthy subjects underwent physical examination were selected as the control group.The levels of MCV,MCH and RDW-CV were detected,and HbA2 was detected by hemoglobin electrophoresis.The diagnostic efficiency of MCV,MCH,RDW-CV and HbA2 for αβ complex thalassemia was evaluated by receiver operating characteristic curve.Results Compared with the control group,the MCV and MCH of the resting,mild and intermediate αβ complex thalassemia groups were decreased,and RDW-CV,HbA2 were increased,the differences were statistically significant(P<0.05).Compared with the intermediate αβ complex thalassemia group,the MCV,MCH and HbA2 in the resting and mild αβ complex thalassemia group were increased,and the RDW-CV were decreased,the differences were statistically significant(P<0.05).The cutoff values of MCV,MCH,RDW-CV and HbA2 for diagnosing αβ complex thalassemia were 78.8 fL,26.65 pg,14.15% and 3.50% respectively,and the areas under the curve were 0.978,0.989,0.959 and 0.999 respectively.Conclusion MCV,MCH,RDW-CV and HbA2 have certain diagnostic value for αβ complex thalassemia,among which the HbA2 has the highest efficiency and could be used for the screening ofαβcomplex thalassemia.
作者
潘美秀
蒙秀坚
韦松晓
李海凤
PAN Meixiu;MENG Xiujian;WEI Songxiao;LI Haifeng(Department of Medical Laboratory,Wuzhou Red Cross Hospital,Wuzhou,Guangxi 543002,China)
出处
《检验医学与临床》
CAS
2022年第9期1193-1195,1200,共4页
Laboratory Medicine and Clinic
基金
广西壮族自治区卫生健康委员会自筹经费科研项目(Z20190727)。
