摘要
新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)和艾滋病(acquired immunodeficiency syndrome, AIDS)均属于乙类传染病,其病原体分别是新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)和人类免疫缺陷病毒(human immunodeficiency virus, HIV)。尽管HIV感染不是COVID-19的风险因素,但最近的临床研究表明,与HIV阴性的COVID-19患者相比,HIV阳性的COVID-19患者临床病程更长,特别是CD4;T淋巴细胞计数较低或未接受抗反转录病毒治疗(antiretroviral therapy, ART)的患者病情更严重。因此,本文将从病原学、感染发病机制两方面比较两种病毒的差异,并阐述HIV阳性的COVID-19患者免疫学和病毒学特征,这将有助于对SARS-CoV-2与HIV感染有更加清晰的认识。
Both coronavirus disease 2019(COVID-19) and acquired immune deficiency syndrome(AIDS) are known as category B infectious diseases, which were caused respectively by SARS-CoV-2 and human immunodeficiency virus(HIV).Although HIV infection is not a risk factor for COVID-19, latest clinical studies have shown that HIV-positive COVID-19 patients experience longer disease course and are more likely to have severe COVID-19 compared with HIV-negative COVID-19 patients, especially those with low CD4;T cells count or with no antiretroviral therapy(ART).In this review, we aim to compare the etiological and pathogenetic differences between COVID-19 and AIDS, and to elucidate the immunological and virologic characteristics of HIV-positive COVID-19 patients, which helps for a better understanding of SARS-CoV-2 and HIV co-infections.
作者
白若靖
吕诗韵
画伟
吴昊
代丽丽
BAI Ruo-jing;Lü Shi-yun;HUA Wei;WU Hao;DAI Li-li(Center for Infectious Diseases,Beijing You’an Hospital,Capital Medical University,Beijing 100069,China;不详)
出处
《中国病毒病杂志》
CAS
2022年第1期64-68,共5页
Chinese Journal of Viral Diseases
基金
国家“十三五”科技重大专项(2018ZX10721-102-003-003,2018ZX10302-102)
北京市科技计划课题(Z211100002921003)
北京市自然科学基金(7222092)。
