摘要
慢性创面具有病因复杂、治疗难度大、致残率及病死率高等特点,中医药治疗方案具有疗效确切、安全可靠等优点。尤其是祛腐中药在治疗过程中发挥重要作用。外用膏剂及洗剂可局部针对性给药、副作用小、祛腐生肌作用明显的优点,其作用机理可能与增强机体及局部巨噬细胞溶酶体活性、加强创面免疫细胞活性细胞氧代谢、改善创面微循环、调节创面pH值调节创面P物质代谢、调控cAMP信号通路、调控PPAR信号通路等诸多途径有关。
Chronic wounds have the characteristics of complex etiology,difficult treatment,disability rate and high mortality.Traditional Chinese medicine treatment has the advantages of exact curative effect,safe and reliable.In particular,Chinese medicine for removing corruption plays an important role in the treatment process.External ointments and lotions can be locally targeted administration,side effects are small,the obvious advantages of the role of anti-corruption muscle,it’s mechanism may be related to the enhancement of the lysosome activity of the body and local macrophages,the enhancement of oxygen metabolism of active cells of wound immune cells,the improvement of wound microcirculation,the regulation of wound pH to regulate substance P metabolism,the regulation of cAMP signaling pathway,and the regulation of PPAR signaling pathway.
作者
王海波
李旭峰
缪东初
WANG Haibo;LI Xufeng;MIAO Dongchu(Jilin People’s Hospital,Jilin Province,Jilin 132000,China;不详)
出处
《中国医学创新》
CAS
2022年第13期175-180,共6页
Medical Innovation of China
基金
2021年度吉林省中医药科技项目(2021191)
吉林省卫生与健康青年科技骨干培养计划项目(2020Q032)。
关键词
祛腐中药
慢性创面
外用
Chinese medicine for dispelling rot
Chronic wounds
External use
