摘要
目的研究脾脏、肝脏弹性模量及肝纤维化4因子指数(FIB-4)对乙肝肝硬化的诊断价值。方法选取2020年10月~2021年8月华北理工大学附属医院收治的107例慢性乙肝患者,根据临床诊断结果分为肝炎组及肝硬化组,分析两组脾脏、肝脏弹性模量及FIB-4的差异以及各参数与肝硬化的相关性。并绘制脾脏、肝脏弹性模量及FIB-4单独及联合诊断肝硬化的ROC曲线。结果肝硬化组脾脏弹性模量、肝脏弹性模量及FIB-4均高于肝炎组,差异有统计学意义(P<0.05)。相关性分析表明,脾脏、肝脏弹性模量、FIB-4均与肝硬化之间呈正相关,其中肝脏弹性模量相关系数最高。脾脏弹性模量、肝脏弹性模量及FIB-4诊断肝硬化的曲线下面积分别为0.89、0.94和0.87,各参数联合诊断效能均大于单一指标。结论脾脏、肝脏弹性值及FIB-4对乙肝肝硬化有良好的诊断价值,且联合诊断肝硬化效果大于单一诊断。
Objective To study the diagnostic value of spleen and liver elastic modulus and liver fibrosis 4 factor index(FIB-4)for hepatitis B cirrhosis.Methods From October 2020 to August 2021,107 chronic hepatitis B patients in our hospital were selected and divided into hepatitis group and cirrhosis group according to the clinical diagnosis results.The differences of spleen and liver elastic modulus and FIB-4 in two groups were analyzed,and the correlation between each parameter and cirrhosis was analyzed.The ROC curves of spleen,liver elastic modulus and FIB-4 alone and combined in the diagnosis of liver cirrhosis were drawn.Results The elastic modulus of spleen,liver and FIB-4 in liver cirrhosis group were significantly higher than those in hepatitis group(P<0.05).Correlation analysis showed that the elastic modulus of spleen,liver and FIB-4 were positively correlated with liver cirrhosis,and the correlation coefficient of liver elastic modulus was the highest.The areas under the curve of spleen elastic modulus,liver elastic modulus and FIB-4 in the diagnosis of liver cirrhosis were 0.89,0.94 and 0.87 respectively.The combined diagnostic efficiency of each parameter was greater than that of a single index.Conclusion The elasticity value of spleen and liver and FIB-4 has a good diagnostic value for hepatitis B cirrhosis,and the combined diagnosis of cirrhosis is more effective than single diagnosis.
作者
陈杉杉
刘洋
王艺桦
陈颖
李鑫淼
张树华
CHEN Shanshan;LIU Yang;WANG Yihua(The Affiliated Hospital of North China University of Science and Technology,Hebei 063000,China)
出处
《医学研究杂志》
2022年第4期86-89,共4页
Journal of Medical Research
关键词
肝硬化
肝脏弹性
脾脏弹性
肝纤维化参数模型
Cirrhosis
Liver elasticity
Spleen elasticity
Hepatic fibrosis parameter model
