摘要
目的 探讨扶正解毒汤对脓毒血症患者临床疗效影响。方法 选取脓毒血症患者92例为研究对象,随机分为2组,每组46例。对照组采用常规西医方法治疗,试验组采用常规法联合扶正解毒汤治疗。对2组脓毒血症患者的治疗效果、急性生理学和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、血清降钙素原(PCT)水平及血流动力学指标水平进行比较。结果 治疗前,2组APACHEⅡ评分、血清CRP、IL-6、PCT水平及血流动力学指标水平比较,差异无统计学意义(P>0.05);治疗后,2组APACHEⅡ评分、血清CRP、IL-6、PCT水平下降,胸腔液体水平(TFC)、系统血管阻力指数(SVRI)水平均下降,平均动脉压(MAP)、心脏指数(CI)水平上升,且试验组APACHEⅡ评分、CRP、IL-6、PCT水平及TFC、SVRI水平低于对照组,MAP、CI水平高于对照组,差异有统计学意义(P<0.05)。与对照组比较,试验组总有效率较高,不良反应发生率较低,差异有统计学意义(P<0.05)。结论 扶正解毒汤对脓毒血症患者疗效较好,可以改善患者血清水平和血流动力学指标,降低不良反应发生率。
Objective To explore the effect of Fuzheng Jiedu Decoction on clinical effects in patients with sepsis. Methods A total of 92 patients with sepsis were selected as research objects, and randomly divided into two groups, with 46 cases in each group. The control group was treated with conventional western medicine, while the test group was treated with conventional therapy and Fuzheng Jiedu Decoction in combination. The therapeutic effects, Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE) score, levels of serum C-reactive protein(CRP), interleukin-6(IL-6), and serum procalcitonin(PCT) as well as levels of hemodynamic indexes in patients with sepsis of two groups were compared and analyzed. Results Before treatment, there were no significant differences in APACHE Ⅱ score, levels of serum CRP, IL-6, PCT and hemodynamic indexes between the two groups(P>0.05). After treatment, the APACHE Ⅱ score, serum CRP, IL-6 and PCT levels decreased, thoracic fluid level(TFC) and systemic vascular resistance index(SVRI) decreased, and the mean arterial pressure(MAP) and cardiac index(CI) increased(P<0.05). The APACHE Ⅱ score, levels of CRP, IL-6, PCT, TFC and SVRI in the test group were lower than those in the control group, and the levels of MAP and CI were higher than those in the control group(P<0.05). Compared with the control group, the total effective rate of the test group was higher and the incidence of adverse reactions was lower, there were significant differences between the two groups(P<0.05). Conclusion Fuzheng Jiedu Decoction has good effects for patients with sepsis, and it can improve the serum levels and hemodynamic indexes of the patients, and reduce the incidence of adverse reactions.
作者
欧哲耀
林文燕
邓小彦
OU Zheyao;LIN Wenyan;DENG Xiaoyan(the Second Department of Brain,Hainan Hospital of Traditional Chinese Medicine,Haikou,Hainan,570203;Emergency Department,the First Affiliated Hospital of Hainan Medical College,Haikou,Hainan,570102)
出处
《实用临床医药杂志》
CAS
2022年第7期22-25,共4页
Journal of Clinical Medicine in Practice
基金
海南省卫生计生行业科研项目(18A200064)。
