摘要
目的研究支气管哮喘合并过敏性鼻炎(AR)患者的肺功能与气道炎性反应特征。方法选取2019年1月至2020年9月我院收治的95例支气管哮喘患者,根据是否合并AR分为合并AR组(n=22)与未合并AR组(n=73),比较两组患者的肺功能指标[第1 s用力呼气容积占预计值的百分比(FEV_(1)%pred)、用力肺活量占预计值的百分比(FVC%pred)、FEV_(1)/FVC]与气道炎性反应指标[呼出气一氧化氮(FeNO)],并且分析支气管哮喘合并AR患者肺功能与气道炎性反应的相关性。结果两组患者的FEV_(1)/FVC比较差异无统计学意义(P>0.05);合并AR组的FEV_(1)%pred、FVC%pred低于未合并AR组,FeNO高于未合并AR组(P<0.05)。经Pearson相关性分析显示,支气管哮喘合并AR患者的FEV_(1)%pred、FVC%pred与FeNO呈负相关(r=-0.489、-0.512,P=0.016、0.024)。结论支气管哮喘合并AR患者肺功能明显降低,而气道炎性反应明显升高,且肺功能与气道炎性反应具有相关性,检测其相关指标有助于支气管哮喘合并AR的临床诊治。
Objective To study the characteristics of pulmonary function and airway inflammation response in patients with bronchial asthma complicated with allergic rhinitis(AR).Methods 95 patients with bronchial asthma admitted to our hospital from January 2019 to September 2020 were divided into AR group(n=22)and non-AR group(n=73)according to complicated AR or none.The pulmonary function indicators[percentage of forced expiratory volume in the first second(FEV_(1)%pred),percentage of forced vital capacity in the predicted value(FVC%pred),FEV_(1)/FVC]and airway inflammatory response indicator[fractional exhaled nitric oxide(FeNO)]were compared between the two groups,and the correlation between pulmonary function and airway inflammatory response in patients with bronchial asthma complicated with AR was analyzed.Results No statistial difference was found in the FEV_(1)/FVC between the two groups(P>0.05).The FEV_(1)%pred and FVC%pred in AR group were lower than those in non-AR group,and FeNO was higher than that in non-AR group(P<0.05).Pearson correlation analysis showed that FEV_(1)%pred and FVC%pred were negatively correlated with FeNO in patients with bronchial asthma complicated with AR(r=-0.489,-0.512,P=0.016,0.024).Conclusions The pulmonary function of patients with bronchial asthma complicated with AR significantly decreases,while the airway inflammatory response significantly increases.Correlation is found between pulmonary function and airway inflammatory response,and the detection of related indicators is helpful to the clinical diagnosis and treatment of bronchial asthma complicated with AR.
作者
耿艺维
吴景硕
张爱新
GENG Yiwei;WU Jingshuo;ZHANG Aixin(Respiratory Intensive Care Unit,Zhengzhou Second People's Hospital,Zhengzhou 450006,China)
出处
《临床医学工程》
2022年第5期653-654,共2页
Clinical Medicine & Engineering
关键词
支气管哮喘
过敏性鼻炎
肺功能
气道炎性反应
相关性
Bronchial asthma
Allergic rhinitis
Pulmonary function
Airway inflammation
Correlation
