摘要
目的:探讨孟鲁司特钠和阿奇霉素联合治疗小儿肺炎支原体继发性哮喘发作的临床效果。方法:本研究纳入200例诊断为继发性哮喘发作的支原体肺炎患儿,依据随机抽签法分为观察组与对照组,各100例。对照组接受阿奇霉素和支气管扩张药或糖皮质激素的联合治疗。观察组在对照组基础上加用孟鲁司特钠联合治疗。比较两组治疗前后的肺功能指标,T淋巴细胞亚群,细胞因子水平,免疫球蛋白G(IgG)和免疫球蛋白M(IgM)阳性率,哮喘控制率和复发率。结果:观察组肺功能各项指标升高明显高于对照组(P<0.05);观察组T淋巴细胞亚群(CD4^(+)、CD4^(+)/CD8^(+))升高明显高于对照组(P<0.05);观察组T淋巴细胞亚群(CD8^(+))下降明显低于对照组(P<0.05);观察组白介素-10(IL-10),白介素-17(IL-17)和转化生长因子-β(TGF-β)水平下降明显低于对照组(P<0.05);两组IgG和IgM阳性率与干预前相比明显下降(P<0.05)。观察组的哮喘控制率高于对照组,哮喘复发率低于对照组(P<0.05)。结论:孟鲁司特钠联合阿奇霉素治疗儿童小儿支原体肺炎并继发性哮喘发作,可缓解炎症反应,增强患者免疫功能,改善肺功能。
Objective:To investigate the clinical effect of montelukast and azithromycin in the treatment of children with secondary asthma attacks of Mycoplasma pneumoniae.Methods:In this study,200 children with mycoplasma pneumonia diagnosed as secondary asthma attack were randomly divided into observation group and control group,with 100 cases in each group.Observation group received montelukast sodium,azithromycin and bronchodilator or glucocorticoid combined treatment.Azithromycin was treated in combination with bronchodilators or glucocorticoids.Lung function indexes,T lymphocyte subsets,cytokine levels,positive rates of immunoglobulin G(IgG)and immunoglobulin M(IgM),asthma control rate and recurrence rate were compared between the two groups before and after treatment.Results:After the intervention,the indexes of pulmonary function in the observation group were significantly higher than those in the control group(P<0.05,and the T lymphocyte subsets(CD4^(+),CD4^(+)/CD8^(+))in the observation group were significantly higher than those in the control group(P<0.05).The decrease of T lymphocyte subsets(CD8^(+))in the observation group was significantly lower than that in the control group(P<0.05).Interleukin-10(IL-10),interleukin-17(IL-17)and transforming growth factor were observed in the observation group-β(TGF-β).The positive rates of IgG and IgM in the observation group were significantly lower than those before the intervention(P<0.05).Conclusion:Montelukast sodium combined with azithromycin in the treatment of mycoplasma pneumonia in children with secondary asthma attack can relieve inflammatory response,enhance the immune function of patients,improve lung function.
作者
宋永会
SONG Yong-hui(Zhengzhou Jinshui District General Hospital,Henan Zhengzhou 450000,China)
出处
《中国药物评价》
2022年第2期176-179,共4页
Chinese Journal of Drug Evaluation
关键词
小儿支原体肺炎
孟鲁司特钠
阿奇霉素
Mycoplasma pneumoniae in children
Montelukast
Azithromycin
